Obesity is a predominant risk factor in ischemic stroke and is commonly comorbid with it. Pathologies following these conditions are associated with systemic and local inflammation. Moreover, there is increasing evidence that the susceptibility for ischemic brain damage increases substantially in experimental models of ischemic stroke with concomitant obesity. Herein, we explore the proinflammatory events that occur during ischemic stroke and obesity, and we discuss the influence of obesity on the inflammatory response and cerebral damage outcomes in experimental models of brain ischemia. In addition, because melatonin is a neurohormone widely reported to exhibit protective effects in various diseases, this study also demonstrates the anti‐inflammatory role and possible mechanistic actions of melatonin in both epidemic diseases. A summary of research findings suggests that melatonin administration has great potential to exert an anti‐inflammatory role and provide protection against obesity and ischemic stroke conditions. However, the efficacy of this hormonal treatment on ischemic stroke with concomitant obesity, when more serious inflammation is generated, is still lacking.

中文翻译：

---

缺血性中风、肥胖和褪黑激素的抗炎作用

肥胖是缺血性中风的主要危险因素，并且通常与它共存。这些病症后的病理与全身和局部炎症有关。此外，越来越多的证据表明，在伴有肥胖的缺血性中风实验模型中，缺血性脑损伤的易感性显着增加。在此，我们探讨了缺血性中风和肥胖期间发生的促炎事件，并在脑缺血实验模型中讨论了肥胖对炎症反应和脑损伤结果的影响。此外，由于褪黑激素是一种广泛报道的神经激素，在各种疾病中表现出保护作用，本研究还证明了褪黑激素在这两种流行病中的抗炎作用和可能的机制作用。研究结果总结表明，褪黑激素给药具有发挥抗炎作用并提供针对肥胖和缺血性中风病症的保护的巨大潜力。然而，当产生更严重的炎症时，这种激素治疗对伴有肥胖的缺血性中风的疗效仍然缺乏。