In Vivo Evaluation of Bioabsorbable Fe‐35Mn‐1Ag: First Reports on In Vivo Hydrogen Gas Evolution in Fe‐Based Implants,Advanced Healthcare Materials

当前位置： X-MOL 学术 › Adv. Healthcare Mater. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

In Vivo Evaluation of Bioabsorbable Fe‐35Mn‐1Ag: First Reports on In Vivo Hydrogen Gas Evolution in Fe‐Based Implants
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2020-11-02 , DOI: 10.1002/adhm.202000667
Matthew Simon Dargusch ₁ , Jeffrey Venezuela ₁ , Ali Dehghan‐Manshadi ₁ , Sean Johnston ₁ , Nan Yang ₁ , Karine Mardon ₂ , Cora Lau ₃ , Rachel Allavena ₄

Affiliation

This work investigates the influence of Ag (1 wt%) on the mechanical properties, in vitro and in vivo corrosion, and biocompatibility of Fe‐35Mn. The microstructure of Fe‐35Mn‐1Ag possesses a uniform dispersion of discrete silver particles. Slight improvements in compressive properties are attributed to enhanced density and low porosity volume. Fe‐35Mn‐1Ag exhibits good in vitro and in vivo corrosion rate of Fe‐35Mn due to an increase in microgalvanic corrosion. Gas pockets, which originate from an inflammatory response to the implants, are observed in the rats after 4 weeks implantation but are undetectable after 12 weeks. No chronic toxicity is observed with the Fe‐35Mn‐1Ag, suggesting acceptable in vivo biocompatibility. The high corrosion rate of the alloy triggers an increased level of nonadverse tissue inflammatory responses 4 weeks after implantation, which subsequently subsides at 12 weeks. The Fe‐35Mn‐1Ag displays properties that are suitable for orthopedic applications.

中文翻译：

体内可生物吸收的Fe-35Mn-1Ag的体内评估：关于基于Fe的植入物中体内氢气逸出的首次报道

这项工作研究了Ag（1 wt％）对Fe-35Mn的机械性能，体外和体内腐蚀以及生物相容性的影响。Fe-35Mn-1Ag的微观结构具有分散的银颗粒的均匀分散。压缩性能的轻微改善归因于密度增加和孔隙率低。由于微电流腐蚀的增加，Fe-35Mn-1Ag在体外和体内均显示出良好的Fe-35Mn腐蚀速率。植入后4周，在大鼠中观察到了源自对植入物的炎症反应的气袋，但在12周后无法检测到。Fe‐35Mn‐1Ag未观察到慢性毒性，表明体内生物相容性可接受。合金的高腐蚀速率会在植入后4周触发非不良组织炎症反应的水平增加，随后在12周时消退。Fe‐35Mn‐1Ag具有适合骨科应用的特性。

更新日期：2020-11-02

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11