TNFα-stimulated gene-6 (TNFAIP6) plays an important role in the prognosis of many tumors. Our objective was to investigate the clinical and prognostic value of TNFAIP6 expression in gastric cancer (GC) patients. Here, we investigated the expression of TNFAIP6 in GC tissues using western blotting and immunohistochemistry and the association between TNFAIP6 expression and the prognosis and clinicopathological parameters of GC patients. Our results revealed that the expression of TNFAIP6 was higher in GC tissue than in normal gastric tissue, and the levels were positively correlated with the depth of tumor invasion (P = 0.010), tumors with lymph node metastasis (P = 0.000) and TNM stage (P = 0.003) of GC patients. Moreover, the results revealed that patients with high TNFAIP6 expression exhibited poorer overall survival than those with low TNFAIP6 expression (P = 0.037). Additionally, knockdown of TNFAIP6 inhibited the proliferation, invasion and metastasis of GC cells in vitro. High TNFAIP6 expression was associated with the depth of tumor invasion, lymph node metastasis, TNM stage and poor prognosis of GC patients, suggesting that TNFAIP6 may serve as a novel indicator of the prognosis and as a treatment target of GC.

TNFα刺激基因6（TNFAIP6）在许多肿瘤的预后中发挥着重要作用。我们的目的是研究胃癌 (GC) 患者中 TNFAIP6 表达的临床和预后价值。在这里，我们使用蛋白质印迹和免疫组织化学研究了GC组织中TNFAIP6的表达以及TNFAIP6表达与GC患者的预后和临床病理参数之间的关联。结果显示，胃癌组织中TNFAIP6的表达高于正常胃组织，且其水平与肿瘤浸润深度（P = 0.010）、肿瘤有无淋巴结转移（P = 0.000）以及TNM分期呈正相关。 (P = 0.003) GC 患者。此外，结果显示，TNFAIP6高表达的患者总体生存率低于TNFAIP6低表达的患者（P = 0.037）。此外，敲低TNFAIP6可抑制体外GC细胞的增殖、侵袭和转移。 TNFAIP6的高表达与GC患者的肿瘤浸润深度、淋巴结转移、TNM分期和不良预后相关，提示TNFAIP6可以作为GC患者预后的新指标和治疗靶点。