Abstract The equilibrium solubility and thermodynamic properties of benflumetol in methanol, ethanol, n-propanol, n-butanol, n-pentanol, n-hexanol, n-heptanol, n-octanol, methyl acetate, ethyl acetate, n-propyl acetate, n-butyl acetate and n-pentyl acetate were reported. Solubility determinations were performed through the laser monitoring method at T = (278.15–323.15) K and p = 101.3 kPa. It is found that the mole fraction solubility of benflumetol increases apparently with the augmented experimental temperature. In addition, the solubility of benflumetol in all ester solvents is greater than that in alcohol solvents. The maximum mole fraction solubility of benflumetol is obtained in n-pentyl acetate (4.061 × 10−2, T = 323.15 K), and the minimum mole fraction solubility of benflumetol is obtained in methanol (1.341 × 10−5, T = 278.15 K). The Hansen solubility parameter for benflumetol as well as selected solvents was summarized to analyse the probabilities of miscibility between solute and solvents. The analysis consequence shows that the miscibility of benflumetol with selected solvents is caused by a combination of factors. All recorded solubility of benflumetol were regressed by λh model, modified Apleblat model, two-Suffix Margules model, NRTL model and UNIQUAC model. By comparison, it can be found that the average ARD and 104 RMSD of the modified Apelblat model and NRTL model are smaller than the other three models, indicating that these two moedls are more suitable for correlating the solubility data. In addition, the apparent thermodynamic properties of benflumetol in all neat solvents were calculated and investigated by the Van't Hoff equation. The results illustrated that the dissolution process of benflumetol is an entropy-driven endothermic process.

中文翻译：

---

苯氟美醇在纯醇和酯溶剂中的溶解度测定、模型评价、汉森溶解度参数和热力学性质

摘要 Benflumetol 在甲醇、乙醇、正丙醇、正丁醇、正戊醇、正己醇、正庚醇、正辛醇、乙酸甲酯、乙酸乙酯、乙酸正丙酯、n报道了乙酸丁酯和乙酸正戊酯。溶解度测定是通过激光监测方法在 T = (278.15–323.15) K 和 p = 101.3 kPa 下进行的。发现苯氟美醇的摩尔分数溶解度随着实验温度的升高而明显增加。此外，苯氟美醇在所有酯类溶剂中的溶解度均大于在醇类溶剂中的溶解度。在乙酸正戊酯 (4.061 × 10−2, T = 323.15 K) 中得到苯氟美醇的最大摩尔分数溶解度，在甲醇中得到苯氟美醇的最小摩尔分数溶解度 (1.341 × 10−5, T = 278.15 K) ）。总结了苯氟美醇的 Hansen 溶解度参数以及选定的溶剂，以分析溶质和溶剂之间的混溶概率。分析结果表明，苯氟美醇与所选溶剂的混溶性是由多种因素共同造成的。所有记录的苯氟美醇溶解度均通过 λh 模型、改进的 Apleblat 模型、二后缀 Margules 模型、NRTL 模型和 UNIQUAC 模型进行回归。通过比较可以发现，修正的 Apelblat 模型和 NRTL 模型的平均 ARD 和 104 RMSD 均小于其他三个模型，表明这两个模型更适合关联溶解度数据。此外，苯氟美醇在所有纯溶剂中的表观热力学性质均通过 Van't Hoff 方程计算和研究。