Abstract The wound healing properties of Teucrium polium L., a plant used in the Algerian traditional medicine for the treatment of wounds, have been investigated using an excision wound model in rabbits. An ointment was prepared with two concentrations (5 and 10%) of a methanolic extract of the aerial parts. Both preparations showed significant effect on the wound contraction when compared to the control and the group treated with petroleum jelly. In addition, acute dermal and oral toxicity was assessed in animal models. The absence of signs of toxicity on the skin of rabbits indicated the safety of the ointment. After oral administration in mice at doses of 1000 and 2000 mg/kg b.wt, no signs of liver and kidney toxicity were detected by analysis of biochemical parameters and by histological examination. The composition of the methanolic extract was investigated by HPLC-PDA-MS analysis, and a comprehensive profile of phenolic compounds was established, with 14 flavonoids and phenylethanoid glycosides identified as the main polyphenolic constituents. Overall, the data support the use of T. polium as a wound healing agent in the Algerian traditional medicine.

中文翻译：

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Teucrium polium - 伤口愈合潜力、毒性和多酚成分

摘要 使用兔切除伤口模型研究了用于治疗伤口的阿尔及利亚传统药物 Teucrium polium L. 的伤口愈合特性。用两种浓度（5% 和 10%）的地上部分甲醇提取物制备软膏。与对照组和凡士林治疗组相比，两种制剂均对伤口收缩有显着影响。此外，在动物模型中评估了急性皮肤和口腔毒性。兔子皮肤没有毒性迹象表明该软膏是安全的。在小鼠中以 1000 和 2000 mg/kg b.wt 的剂量口服给药后，通过生化参数分析和组织学检查未检测到肝和肾毒性迹象。通过 HPLC-PDA-MS 分析研究了甲醇提取物的组成，并建立了酚类化合物的综合概况，其中 14 种黄酮类化合物和苯乙醇苷被确定为主要的多酚成分。总体而言，数据支持使用 T. polium 作为阿尔及利亚传统医学中的伤口愈合剂。