Flash technology-based self-assembly in nanoformulation: Fabrication to biomedical applications,Materials Today

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Flash technology-based self-assembly in nanoformulation: Fabrication to biomedical applications
Materials Today ( IF 21.1 ) Pub Date : 2020-11-01 , DOI: 10.1016/j.mattod.2020.08.019
Hanze Hu ₁ , Chao Yang _{1,

2} , Mingqiang Li ₃ , Dan Shao ₂ , Hai-Quan Mao ₄ , Kam W Leong _{1,

5}

Affiliation

Abstract Advances in nanoformulation have driven progress in biomedicine by producing nanoscale tools for biosensing, imaging, and drug delivery. Flash-based technology, the combination of rapid mixing technique with the self-assembly of macromolecules, is a new engine for the translational nanomedicine. Here, we review the state-of-the-art in flash-based self-assembly including theoretical and experimental principles, mixing device design, and applications. We highlight the fields of flash nanocomplexation (FNC) and flash nanoprecipitation (FNP), with an emphasis on biomedical applications of FNC, and discuss challenges and future directions for flash-based nanoformulation in biomedicine.

中文翻译：

基于闪存技术的纳米配方自组装：生物医学应用的制造

摘要纳米制剂的进步通过生产用于生物传感、成像和药物输送的纳米级工具推动了生物医学的进步。基于Flash的技术将快速混合技术与大分子自组装相结合，是转化纳米医学的新引擎。在这里，我们回顾了基于闪存的自组装的最新技术，包括理论和实验原理、混合装置设计和应用。我们重点介绍快速纳米络合（FNC）和快速纳米沉淀（FNP）领域，重点关注FNC的生物医学应用，并讨论基于快速纳米制剂在生物医学中的挑战和未来方向。

更新日期：2020-11-01

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