Abstract The duty cycle is a critical parameter affecting the sensitivity of analyses by Time-of-Flight Mass Spectrometers with Orthogonal Accelerators (OA-TOFMS). Improving the duty cycle becomes especially critical for the analytical performance of high-resolution TOFMS (HR-TOFMS) with elongated ion paths, such as based on multi-reflecting types of mass analyzers. Currently used methods for improving the duty cycle are based on accumulating ions in various trapping devices between push pulses. These methods do not always provide the best analytical results, may create conditions for secondary reactions, and require adjusting acquisition conditions to maximize the effect. The Encoded Frequent Pushing® (EFP®) method is the spectral multiplexing technique developed for improving the duty cycle of the HR-TOFMS. We report on the implementation of the EFP in HR-TOFMS with a Folded Flight Path® mass analyzer coupled with gas chromatography (GC) and two-dimensional comprehensive GC (GCxGC) for analysis of complex mixtures. This approach is expected to benefit the results of analysis of complex samples by improving limits of detection and mass spectra quality.

中文翻译：

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改进折叠飞行路径高分辨率飞行时间质谱仪的占空比

摘要 占空比是影响带正交加速器的飞行时间质谱仪 (OA-TOFMS) 分析灵敏度的关键参数。提高占空比对于具有细长离子路径的高分辨率 TOFMS (HR-TOFMS) 的分析性能尤其重要，例如基于多反射类型的质量分析器。目前用于改善占空比的方法是基于在推动脉冲之间的各种捕获装置中积累离子。这些方法并不总能提供最好的分析结果，可能会为二次反应创造条件，并且需要调整采集条件以最大化效果。Encoded Frequency Pushing® (EFP®) 方法是为改善 HR-TOFMS 的占空比而开发的频谱复用技术。我们报告了 EFP 在 HR-TOFMS 中的实施，使用 Folded Flight Path® 质量分析器与气相色谱 (GC) 和二维综合 GC (GCxGC) 相结合，用于分析复杂的混合物。这种方法有望通过提高检测限和质谱质量来改善复杂样品的分析结果。