BACKGROUND The roles of pro-inflammatory microparticles, pro-inflammatory cytokines and oxidative stress were unknown in elderly patients with recurrent ventricular arrhythmias (VA). We evaluated whether cross talk between oxidative stress, pro-inflammatory microparticles, and pro-inflammatory cytokines play the roles in elderly patients with recurrent VA after coronary stenting. This research sought to investigate the effects of oxidative stress, pro-inflammatory microparticles, and pro-inflammatory cytokines on recurrent VA in elderly patients after coronary stenting. METHODS In this study, we included 613 consecutive elderly patients with recurrent ventricular arrhythmias induced by coronary reocclusions after coronary stenting. We measured CD31+ endothelial microparticle (CD31+EMP), CD62E+ endothelial microparticle (CD62E+EMP), high-sensitivity C-reactive protein (hs-CRP), aldosterone (ALD), malondialdehyde (MDA), tumor necrosis factor-α (TNF-α), soluble tumor necrosis factor receptor-1 (sTNFR-1) and soluble tumor necrosis factor receptor-2 (sTNFR-2) in elderly patients with recurrent VA and assessed impacts of pro-inflammatory microparticles, pro-inflammatory cytokines and oxidative stress on recurrent VA in elderly patients after coronary stenting. RESULTS The levels of CD31+EMP, CD62E+EMP, hs-CRP, ALD, MDA, TNF-α, sTNFR-1 and sTNFR-2 were increased in recurrent malignant ventricular arrhythmia, sustained ventricular tachycardia, multiple ventricular premature beat and left and right ventricular bundle branch block groups (P < 0.001) in elderly patients with coronary reocclusions after coronary stent implantation. Upregulation of pro-inflammatory microparticles, pro-inflammatory cytokines and oxidative stress markers induced recurrent VA in elderly patients after coronary stenting. CONCLUSIONS High levels of pro-inflammatory microparticles, pro-inflammatory cytokines and oxidative stress markers were associated with recurrent VA in elderly patients after coronary stenting. Our results suggested that the pro-inflammatory microparticles, pro-inflammatory cytokines and oxidative stress may simultaneously induce and aggravate recurrent VA in elderly patients after coronary stenting.

中文翻译：

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冠状动脉支架植入术后老年患者促炎细胞因子、促炎微粒与氧化应激和复发性室性心律失常的相互作用

背景 在患有复发性室性心律失常 (VA) 的老年患者中，促炎微粒、促炎细胞因子和氧化应激的作用尚不清楚。我们评估了氧化应激、促炎微粒和促炎细胞因子之间的串扰是否在冠状动脉支架置入术后复发性 VA 的老年患者中发挥作用。本研究旨在探讨氧化应激、促炎微粒和促炎细胞因子对冠状动脉支架置入术后老年患者复发性 VA 的影响。方法 在这项研究中，我们连续纳入了 613 名因冠状动脉支架置入术后冠状动脉再闭塞引起的复发性室性心律失常的老年患者。我们测量了 CD31+ 内皮微粒 (CD31+EMP)、CD62E+ 内皮微粒 (CD62E+EMP)、高敏 C 反应蛋白 (hs-CRP)、醛固酮 (ALD)、丙二醛 (MDA)、肿瘤坏死因子-α (TNF-α)、可溶性肿瘤坏死因子受体-1 (sTNFR-1) 和可溶性肿瘤坏死因子受体-2（sTNFR-2）在老年复发性 VA 患者中的研究，并评估了促炎微粒、促炎细胞因子和氧化应激对冠状动脉支架置入术后老年患者复发性 VA 的影响。结果 复发性恶性室性心律失常、持续性室性心动过速、多发性室性早搏和左、右室性早搏中CD31+EMP、CD62E+EMP、hs-CRP、ALD、MDA、TNF-α、sTNFR-1和sTNFR-2水平升高。冠状动脉支架置入术后冠状动脉再闭塞的老年患者右心室束支传导阻滞组（P < 0.001）。促炎微粒的上调，促炎细胞因子和氧化应激标志物诱导老年患者冠状动脉支架置入术后复发性 VA。结论 高水平的促炎微粒、促炎细胞因子和氧化应激标志物与老年患者冠状动脉支架置入术后复发性 VA 相关。我们的研究结果表明，促炎微粒、促炎细胞因子和氧化应激可能同时诱导和加重老年患者冠状动脉支架置入术后 VA 的复发。