Periodontitis is a chronic inflammatory disease with a complex underlying immunopathology. Cytokines, as molecular mediators of inflammation, play a role in all stages of disease progression. T helper 17 (Th17) cells are thought to play a role in periodontitis. Th17 cell development and maintenance requires a pro-inflammatory cytokine milieu, with many of the cytokines implicated in the pathogenesis of periodontitis. Serum and saliva are easily accessible biofluids which can represent the systemic and local environment to promote the development of Th17 cells. Here we review human clinical studies that investigate IL-1β, IL-4, IL-6, IL-10, IL-17A, IL-17F, IL-21, IL-22, IL-23, IL-25, IL-31, IL-33, IFN-γ, sCD40L and TNF-α in serum and saliva in periodontitis. We highlight their putative role in the pathogenesis of periodontitis and place them within a wider context of animal and other clinical studies.

中文翻译：

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牙周炎患者血清和唾液中 T 辅助 17 细胞相关细胞因子的研究

牙周炎是一种慢性炎症性疾病，具有复杂的潜在免疫病理学。细胞因子作为炎症的分子介质，在疾病进展的所有阶段都发挥着作用。T 辅助 17 (Th17) 细胞被认为在牙周炎中起作用。Th17 细胞的发育和维持需要促炎细胞因子环境，其中许多细胞因子与牙周炎的发病机制有关。血清和唾液是易于获取的生物流体，可以代表全身和局部环境，促进 Th17 细胞的发育。在这里，我们回顾了研究 IL-1β、IL-4、IL-6、IL-10、IL-17A、IL-17F、IL-21、IL-22、IL-23、IL-25、IL-的人类临床研究。 31、牙周炎血清和唾液中的IL-33、IFN-γ、sCD40L和TNF-α。