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Intrinsic connectivity of anterior temporal lobe relates to individual differences in semantic retrieval for landmarks
Cortex ( IF 3.6 ) Pub Date : 2020-10-31 , DOI: 10.1016/j.cortex.2020.10.007
Tirso Rj Gonzalez Alam 1 , Katya Krieger-Redwood 1 , Megan Evans 1 , Grace E Rice 2 , Jonathan Smallwood 1 , Elizabeth Jefferies 1
Affiliation  

Contemporary neuroscientific accounts suggest that ventral anterior temporal lobe (ATL) acts as a bilateral heteromodal semantic hub, which is particularly critical for the specific-level knowledge needed to recognise unique entities, such as familiar landmarks and faces. There may also be graded functional differences between left and right ATL, relating to effects of modality (linguistic versus non-linguistic) and category (e.g., knowledge of people and places). Individual differences in intrinsic connectivity from left and right ATL might be associated with variation in semantic categorisation performance across these categories and modalities. We recorded resting-state fMRI in 74 individuals and, in a separate session, examined semantic categorisation. People with greater connectivity between left and right ATL were more efficient at categorising landmarks (e.g., Eiffel Tower), especially when these were presented visually. In addition, participants who showed stronger connectivity from right than left ATL to medial occipital cortex showed more efficient semantic categorisation of landmarks regardless of modality of presentation. These results can be interpreted in terms of graded differences in the patterns of connectivity across left and right ATL, which give rise to a bilateral yet partially segregated semantic ‘hub’. More specifically, right ATL connectivity supports the efficient semantic categorisation of landmarks.



中文翻译:

前颞叶的内在连通性与地标语义检索中的个体差异有关

当代神经科学的研究表明,腹侧前颞叶(ATL)充当了双边异质语义语义枢纽,这对于识别独特实体(例如熟悉的地标和面孔)所需的特定级别的知识尤其重要。左ATL和右ATL之间也可能存在分级的功能差异,涉及模式(语言与非语言)和类别(例如,人和地方的知识)的影响。左ATL和右ATL在内部连接性方面的个体差异可能与这些类别和方式上语义分类性能的变化有关。我们记录了74个人的静止状态功能磁共振成像,并在一个单独的会话中,检查了语义分类。左右ATL之间具有更大连通性的人在对地标(例如艾菲尔铁塔)进行分类时效率更高,尤其是在视觉上呈现这些地标时。此外,无论呈现方式如何,从右ATL到左枕内侧皮层的连接性都强于左侧枕骨的参与者显示出更有效的地标语义分类。这些结果可以用左右ATL之间的连接模式的分级差异来解释,这引起了双边但部分隔离的语义“枢纽”。更具体地说,正确的ATL连接性支持地标的有效语义分类。参与者表现出从右ATL到左枕骨皮质的连接性强于人,而无论呈现方式如何,都对地标的语义分类更加有效。这些结果可以用左右ATL之间的连接模式的分级差异来解释,这引起了双边但部分隔离的语义“枢纽”。更具体地说,正确的ATL连接性支持地标的有效语义分类。参与者表现出从右ATL到左枕骨皮质的连接性强于人,而无论呈现方式如何,都对地标的语义分类更加有效。这些结果可以用左右ATL之间的连接模式的分级差异来解释,这引起了双边但部分隔离的语义“枢纽”。更具体地说,正确的ATL连接性支持地标的有效语义分类。

更新日期:2020-12-01
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