The comparative kinetic analysis of total hypericin (TH) extraction from the pre-extracted flowers of Hypericum perforatum carried out under simultaneous external physical field and cooling reaction system operational conditions (SEPFC) was performed. The kinetics curves of TH extraction in SEPFC were measured in the temperature range from T = 298 to 328 K. It was proved that presence of ultrasonic and microwave field cause increasing of the extraction rate compared to conventional isothermal extraction. The possibility of describing the kinetics of TH extraction in SEPFC with empirical (Elovich's model) and physically-based (film-theory model) were explored. The kinetic complexity of the process was examined with the differential isoconversional method. By applying the model-fitting method the proper kinetic model of TH extraction in SEPFC was found: [1 − (1 − α)^(1/3)]² = k_M · t. The values of the extraction rate constant (k_M), activation energy (E_a) and pre-exponential factor (ln A) of TH extraction were calculated. The effect of ultrasonic and microwave field on (a) k_M; (b) E_a and (c) ln A of TH extraction was determined. The model mechanism of activation of hypericin molecule for extraction in SEPFC conditions was proposed. The values of wave number of resonant vibrations, vibration quantum number and anharmonicity parameter for the TH extraction are obtained.

在同时进行的外部物理场和冷却反应系统操作条件（SEPFC）下进行了从贯叶连翘提取物中提取的总金丝桃素（TH）的比较动力学分析。在T的温度范围内测量了SEPFC中TH萃取的动力学曲线。 = 298至328K。事实证明，与传统的等温萃取相比，超声波和微波场的存在导致萃取速率的提高。探索了用经验（Elovich模型）和基于物理（膜理论模型）描述SEPFC中TH萃取动力学的可能性。该过程的动力学复杂性用微分同转化方法进行了检验。通过应用模型拟合方法，发现了SEPFC中TH提取的合适动力学模型：[1-（1-  α）^（1/3） ] ²  =  k _M  ·  t。提取速率常数（k _M），活化能（E _a）和TH提取的指数前因数（ln  A）。超声波和微波场对（a）k _M的影响；（b）中Ë_一个和（c）LN 甲TH提取的测定。提出了在SEPFC条件下金丝桃素分子激活提取的模型机制。获得了用于TH提取的共振振动波数，振动量子数和非谐参数。