Bioorganic & Medicinal Chemistry ( IF 3.3 ) Pub Date : 2020-10-31 , DOI: 10.1016/j.bmc.2020.115831 Kyohei Muguruma 1 , Ambara R Pradipta 1 , Yudai Ode 1 , Kazuki Terashima 1 , Hiroyuki Michiba 1 , Motoko Fujii 1 , Katsunori Tanaka 2
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Acrolein, a highly reactive α,β-unsaturated aldehyde, is a compound to which humans are exposed in many different situations and often causes various human diseases. This paper summarizes the reports over the past twenty-five years regarding disease-associated acrolein detected in clinical patients and the role acrolein plays in various diseases. In several diseases, it was found that the increased acrolein acts as a pathogenetic factor. Thus, we propose the utility of over-produced acrolein as a substrate for a promising therapeutic or diagnostic method applicable to a wide range of diseases based on an in vivo synthetic chemistry strategy.
中文翻译：
疾病相关的丙烯醛：体内合成化学的可能诊断和治疗底物
丙烯醛是一种高反应性的α，β-不饱和醛，是人类在许多不同情况下都会暴露的化合物，通常会导致各种人类疾病。本文总结了过去25年中有关在临床患者中发现的与疾病相关的丙烯醛及其在各种疾病中的作用的报告。在几种疾病中，发现增加的丙烯醛是致病因素。因此，我们提出了基于体内合成化学策略，过量生产的丙烯醛作为有前途的可用于多种疾病的治疗或诊断方法的底物的实用性。
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