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Central Nervous System Manifestations Associated with COVID-19
Current Neurology and Neuroscience Reports ( IF 4.8 ) Pub Date : 2020-10-30 , DOI: 10.1007/s11910-020-01079-7
Afshin A Divani 1 , Sasan Andalib 1, 2, 3 , José Biller 4 , Mario Di Napoli 5 , Narges Moghimi 1 , Clio A Rubinos 6 , Christa O'Hana Nobleza 7 , P N Sylaja 8 , Michel Toledano 9 , Simona Lattanzi 10 , Louise D McCullough 11 , Salvador Cruz-Flores 12 , Michel Torbey 1 , M Reza Azarpazhooh 13
Affiliation  

Purpose of Review

Coronavirus disease 2019 (COVID-19) has become a global health crisis of our time. The disease arises from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that binds to angiotensin-converting enzyme 2 (ACE2) receptors on host cells for its internalization. COVID-19 has a wide range of respiratory symptoms from mild to severe and affects several other organs, increasing the complexity of the treatment. There is accumulating evidence to suggest that SARS-CoV-2 can target the nervous system. In this review, we provide an account of the COVID-19 central nervous system (CNS) manifestations.

Recent Findings

A broad spectrum of the CNS manifestations including headache, impaired consciousness, delirium, loss of smell and taste, encephalitis, seizures, strokes, myelitis, acute disseminated encephalomyelitis, neurogenic respiratory failure, encephalopathy, silent hypoxemia, generalized myoclonus, neuroleptic malignant syndrome and Kawasaki syndrome has been reported in patients with COVID-19.

Summary

CNS manifestations associated with COVID-19 should be considered in clinical practice. There is a need for modification of current protocols and standing orders to provide better care for COVID-19 patients presenting with neurological symptoms.



中文翻译:

与 COVID-19 相关的中枢神经系统表现

审查目的

2019 年冠状病毒病 (COVID-19) 已成为我们这个时代的全球健康危机。该疾病源于严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2),它与宿主细胞上的血管紧张素转换酶 2 (ACE2) 受体结合并内化。COVID-19 具有从轻微到严重的各种呼吸道症状,并影响其他几个器官,增加了治疗的复杂性。越来越多的证据表明 SARS-CoV-2 可以针对神经系统。在这篇综述中,我们提供了 COVID-19 中枢神经系统 (CNS) 表现的说明。

最近的发现

广泛的中枢神经系统表现,包括头痛、意识障碍、谵妄、嗅觉和味觉丧失、脑炎、癫痫发作、中风、脊髓炎、急性播散性脑脊髓炎、神经源性呼吸衰竭、脑病、无症状性低氧血症、全身性肌阵挛、抗精神病药恶性综合征和川崎在 COVID-19 患者中报告了该综合征。

概括

在临床实践中应考虑与 COVID-19 相关的 CNS 表现。需要修改当前的协议和常规命令,以便为出现神经系统症状的 COVID-19 患者提供更好的护理。

更新日期:2020-11-02
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