Central Nervous System Manifestations Associated with COVID-19,Current Neurology and Neuroscience Reports

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Central Nervous System Manifestations Associated with COVID-19
Current Neurology and Neuroscience Reports ( IF 4.8 ) Pub Date : 2020-10-30 , DOI: 10.1007/s11910-020-01079-7
Afshin A Divani ₁ , Sasan Andalib _{1,

2,

3} , José Biller ₄ , Mario Di Napoli ₅ , Narges Moghimi ₁ , Clio A Rubinos ₆ , Christa O'Hana Nobleza ₇ , P N Sylaja ₈ , Michel Toledano ₉ , Simona Lattanzi ₁₀ , Louise D McCullough ₁₁ , Salvador Cruz-Flores ₁₂ , Michel Torbey ₁ , M Reza Azarpazhooh ₁₃

Affiliation

Department of Neurology, School of Medicine, University of New Mexico, Albuquerque, NM, USA.
Research Unit of Clinical Physiology and Nuclear Medicine, Department of Nuclear Medicine, Odense University Hospital, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.
Neuroscience Research Center, Department of Neurosurgery, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Department of Neurology, Loyola University, Stritch School of Medicine, Maywood, IL, USA.
Department of Neurology and Stroke Unit, San Camillo de' Lellis District General Hospital, Rieti, Italy.
Department of Neurology, University of North Carolina, Chapel Hill, NC, USA.
Department of Neurology, The University of Mississippi Medical Center, Jackson, MS, USA.
Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India.
Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Neurological Clinic, Department of Experimental and Clinical Medicine, Marche Polytechnic University, Ancona, Italy.
Department of Neurology, McGovern Medical School, The University of Texas at Houston, Houston, TX, USA.
Neurology Department, Texas Tech Health University, Health Sciences Center, El Paso, El Paso, TX, USA.
Departments of Clinical Neurological sciences, Western University, London, Canada.

Purpose of Review

Coronavirus disease 2019 (COVID-19) has become a global health crisis of our time. The disease arises from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that binds to angiotensin-converting enzyme 2 (ACE2) receptors on host cells for its internalization. COVID-19 has a wide range of respiratory symptoms from mild to severe and affects several other organs, increasing the complexity of the treatment. There is accumulating evidence to suggest that SARS-CoV-2 can target the nervous system. In this review, we provide an account of the COVID-19 central nervous system (CNS) manifestations.

Recent Findings

A broad spectrum of the CNS manifestations including headache, impaired consciousness, delirium, loss of smell and taste, encephalitis, seizures, strokes, myelitis, acute disseminated encephalomyelitis, neurogenic respiratory failure, encephalopathy, silent hypoxemia, generalized myoclonus, neuroleptic malignant syndrome and Kawasaki syndrome has been reported in patients with COVID-19.

Summary

CNS manifestations associated with COVID-19 should be considered in clinical practice. There is a need for modification of current protocols and standing orders to provide better care for COVID-19 patients presenting with neurological symptoms.

中文翻译：

与 COVID-19 相关的中枢神经系统表现

审查目的

2019 年冠状病毒病 (COVID-19) 已成为我们这个时代的全球健康危机。该疾病源于严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2)，它与宿主细胞上的血管紧张素转换酶 2 (ACE2) 受体结合并内化。COVID-19 具有从轻微到严重的各种呼吸道症状，并影响其他几个器官，增加了治疗的复杂性。越来越多的证据表明 SARS-CoV-2 可以针对神经系统。在这篇综述中，我们提供了 COVID-19 中枢神经系统 (CNS) 表现的说明。