Yeast and cancer cells are metabolically similar as they use fermentation of glucose as a primary means of generating energy. Reliance on glucose fermentation makes both of these cell types highly sensitive to the toxic glucose analog, 2-deoxyglucose. Here we review the cellular and metabolic pathways that play a role in 2-deoxyglucose sensitivity and discuss how the modifications to these pathways result in acquisition of 2-deoxyglucose resistance. Insights gained from genetic and proteomic studies in yeast provide new ideas for the design of combinatorial therapies for cancer treatment.

中文翻译：

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“糖衣” 2-脱氧葡萄糖：抑制其毒性作用的机制

酵母和癌细胞在代谢上相似，因为它们使用葡萄糖发酵作为产生能量的主要手段。对葡萄糖发酵的依赖使这两种细胞类型对毒性葡萄糖类似物2-脱氧葡萄糖高度敏感。在这里，我们审查了在2-脱氧葡萄糖敏感性中起作用的细胞和代谢途径，并讨论了对这些途径的修饰如何导致2-脱氧葡萄糖抗性的获得。从酵母的遗传和蛋白质组学研究中获得的见识为设计用于癌症治疗的组合疗法提供了新思路。