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Recent Advances in the Microwave Assisted Synthesis of Benzofuran and Indole Derivatives
Heterocycles ( IF 0.6 ) Pub Date : 2020-10-27 , DOI: 10.3987/rev-20-sr(k)1
Gopinathan Anilkumar , Thaipparambil Aneeja , C M A Afsina


Abstract – Microwave (MW) assisted syntheses are environment friendly, efficient, rapid and convenient methodology for the synthesis of organic compounds. Benzene ring fused to a five membered ring containing N or O atom exhibits wide range of biological activities. Benzofuran is present in polymers, pharmaceuticals, and bioactive natural products. Benzofuran is significant as insecticides, herbicides, anti-inflammatory and anti-viral agents. Indoles are well known scaffold showing noteworthy activities like anti-tumor, anti-viral, anti-microbial and anti-oxidant. Indole derivatives are valuable moiety in different therapeutically active drug molecules. On account of the biological significance of benzofuran and indole scaffold, this review describes the recent advances in microwave assisted synthesis of benzofurans and indoles, and covers literature from 2012-2020.


中文翻译:

微波辅助合成苯并呋喃和吲哚衍生物的最新进展


摘要–微波(MW)辅助合成是一种环境友好,高效,快速且方便的有机化合物合成方法。与含有N或O原子的五元环稠合的苯环具有广泛的生物活性。苯并呋喃存在于聚合物,药物和生物活性天然产物中。苯并呋喃作为杀虫剂,除草剂,抗炎剂和抗病毒剂具有重要意义。吲哚是众所周知的支架,显示出值得注意的活性,如抗肿瘤,抗病毒,抗微生物和抗氧化剂。吲哚衍生物是不同治疗活性药物分子中的有价值部分。考虑到苯并呋喃和吲哚支架的生物学意义,本综述描述了微波辅助合成苯并呋喃和吲哚的最新进展,
更新日期:2020-10-27
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