Pisonia aculeata L. (Nyctaginaceae), commonly called Devil's Claws or Pullback, is a folk medicinal plant of India. Herbal medicines due to lesser/no side effect, are being accepted by the society increasingly. Here, we investigated the protective effects of ethanol extract of P. aculeata leaves on cisplatin induced nephrotoxicity. Cisplatin (3 mg/kg, i.p.) co-administered to vehicle and extract (200, 400, 600 mg/kg)-fed rats every 5^th day for 25 days. Serum level of urea, uric acid, creatinine, blood urea nitrogen, phospholipid and cholesterol increased, whereas urine urea, uric acid, creatinine, creatinine clearance rate was reduced in cisplatin control group. Cisplatin also negatively alters electrolyte balance, Na⁺/K⁺-ATPase activity and redox balance significantly. Treatment with extract for 21 days exerted beneficial effect and ameliorated urine and serum biochemical parameter to normal. Extracts induced a rise in Na⁺/K⁺-ATPase activity, and ameliorated level of different enzymatic and non-enzymatic antioxidants positively, whereas lipid peroxidation decreased significantly. Ethanol extract (400 and 600 mg/kg) ameliorated cisplatin-induced nephrotoxicity and other damaging effects caused by cisplatin evidenced by the change in its intrinsic biochemical/antioxidant properties. Taking into account these results, it can be assumed that P. aculeata leaves could be a future key candidate which may maximize the clinical use of cisplatin in the treatment of different cancer without nephrotoxicity.

中文翻译：

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Pisonia aculeata L.叶提取物对顺铂诱导的实验性啮齿动物的肾毒性和肾功能损害的肾脏保护活性。

Pisonia aculeata L.（Nyctaginaceae），通常称为魔鬼的爪子或回扣，是印度的民间药用植物。由于较少/没有副作用的草药被社会越来越接受。在这里，我们调查了体育草叶片乙醇提取物对顺铂诱导的肾毒性的保护作用。顺铂（3毫克/千克，腹膜）共施用到车辆和提取物（200，400，600毫克/千克） -喂食的大鼠，每5^个天25天。顺铂对照组血清尿素，尿酸，肌酐，血尿素氮，磷脂和胆固醇水平升高，而尿尿，尿酸，肌酐，肌酐清除率降低。顺铂还负面改变电解质平衡，Na ⁺ / K⁺ -ATPase活性和氧化还原平衡显着。提取物治疗21天发挥了有益的作用，并改善了尿液和血清生化指标，使其恢复正常。提取物可诱导Na ⁺ / K ⁺ -ATPase活性升高，并积极改善不同酶抗氧化剂和非酶抗氧化剂的水平，而脂质过氧化作用则明显降低。乙醇提取物（400和600 mg / kg）改善了顺铂引起的肾毒性和顺铂引起的其他破坏性作用，其内在的生化/抗氧化特性发生了变化。考虑到这些结果，可以假定为P. aculeata叶子可能是未来的关键候选对象，可以最大程度地利用顺铂治疗各种没有肾毒性的癌症。