Objective. This study employs a human head model with real skull to demonstrate the feasibility of transcranial acoustoelectric brain imaging (tABI) as a new modality for electrical mapping of deep dipole sources during treatment of epilepsy with much better resolution and accuracy than conventional mapping methods. Approach. This technique exploits an interaction between a focused ultrasound (US) beam and tissue resistivity to localize current source densities as deep as 63 mm at high spatial resolution (1 to 4 mm) and resolve fast time-varying currents with sub-ms precision. Main results. Detection thresholds through a thick segment of the human skull at biologically safe US intensities was below 0.5 mA and within range of strong currents generated by the human brain. Significance. This work suggests that 4D tABI may emerge as a revolutionary modality for real-time high-resolution mapping of neuronal currents for the purpose of monitoring, staging,...

中文翻译：

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人头部体模中深偶极子的声电成像指导癫痫治疗

客观的。本研究采用具有真实颅骨的人头模型来证明经颅声电脑成像 (tABI) 作为癫痫治疗期间深部偶极源电映射的新模式的可行性，其分辨率和准确性比传统映射方法要好得多。方法。该技术利用聚焦超声 (US) 束和组织电阻率之间的相互作用，以高空间分辨率（1 至 4 mm）定位深达 63 mm 的电流源密度，并以亚毫秒精度解析快速时变电流。主要结果。在生物安全的 US 强度下，通过人类头骨厚段的检测阈值低于 0.5 mA，并且在人脑产生的强电流范围内。意义。