The temperature conditions for photodynamic therapy of the culture of tumour cells organised in 3D spheroids are studied. The spheroids are placed in the cell culture medium in the well of a special cell culture plate with absorbing walls. A mathematical model is presented that describes the temperature distribution in a well with a cell culture plate heated by optical radiation. It is shown that the temperature in the well volume is not uniformly distributed, and the temperature on the well surface can differ significantly from the temperature in its volume.

中文翻译：

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评估具有吸收壁的细胞培养板中的温度变化，该吸收壁包含在光学范围内照射下的肿瘤球体 3D 模型

研究了在 3D 球体中组织的肿瘤细胞培养物的光动力疗法的温度条件。将球体置于具有吸收壁的特殊细胞培养板的孔中的细胞培养基中。提出了一个数学模型，该模型描述了带有由光辐射加热的细胞培养板的孔中的温度分布。结果表明，井体积内的温度分布不均匀，井表面温度与其体积内的温度可能存在显着差异。