In this paper, we describe a novel fabrication method of a microfluidic integrated surface plasmon resonance (SPR) gold chip based on a (3-mercaptopropyl) trimethoxy silane (MPTMS) self-assembled monolayer. This monolayer was formed at the surface of a microfluidic chip made of polydimethylsiloxane (PDMS). Its presence was confirmed by contact angle and Fourier transform infrared spectroscopy measurements on the modified PDMS surface. A basic, but nevertheless appropriate, 4-channel microfluidic system was made on PDMS and reported on a gold SPR sensor. Sealing tests were carried-out by injecting continuous flows of solutions under gradient pressure up to 1.8 bar. Bonding strength of chemical and corona binding were measured and compared. The test of the integrated microfluidic SPR sensor on an SPR bench validated its functionality and proved as well that no leakage is observed between the different microfluidic channels.

中文翻译：

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用于表面等离子体共振应用的无泄漏集成微流体通道制造

在本文中，我们描述了一种基于（3-巯基丙基）三甲氧基硅烷（MPTMS）自组装单层的微流集成表面等离子体共振（SPR）金芯片的新型制造方法。该单层形成在由聚二甲基硅氧烷（PDMS）制成的微流体芯片的表面上。通过在改性的PDMS表面上的接触角和傅立叶变换红外光谱法测量证实了它的存在。在PDMS上建立了一个基本但仍然合适的4通道微流控系统，并在Gold SPR传感器上进行了报道。通过在不超过1.8 bar的梯度压力下注入溶液的连续流来进行密封测试。测量和比较化学和电晕结合的结合强度。