Meteorin-like (Metrnl) is an adipokine with insulin sensitizing and anti-inflammatory properties that has been discovered recently. The relation among Metrnl, Inflammatory Bowel Disease (IBD), and obesity has been unexplored yet. The present study was conducted on 54 healthy control, 42 Ulcerative Colitis (UC), and 43 Crohn’s disease (CD) patients who were diagnosed by pathological examination. In all participants, serum levels of adiponectin, Metrnl, interleukin (IL)-6, and Tumor necrosis factor (TNF-α) were measured using ELISA kits. Metrnl concentration was considerably lower in both UC (85.25 ± 36.55 pg/mL) and CD (76.93 ± 27.92 pg/mL) patients in comparison to control (107.52 ± 35.33 pg/mL). In addition, it was seen that both patient groups have a decreased level of adiponectin compared to the controls. Besides that, the level of IL-6 and TNF-α were significantly greater in the patient groups. Moreover, the result showed that the level of Metrnl is inversely correlated with body mass index (BMI) in the controls and the patients. Metrnl levels are also inversely associated with IL-6, and TNF-α in both of the patient groups. The current study is the first one reporting the decreased levels of Metrnl in serum among patients with IBD, which is inversely related with BMI, TNF-α, and IL-6. These results suggested a possible relation of Metrnl with the pathogenesis of IBD, particularly through inflammatory process, although further studies are warranted to dissect the possible mechanism.

中文翻译：

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炎症性肠病患者血清 Meteorin 样水平的特征及其与炎症细胞因子的关系

镍纹蛋白样 (Metrnl) 是一种最近发现的具有胰岛素敏化和抗炎特性的脂肪因子。Metrnl、炎症性肠病 (IBD) 和肥胖之间的关系尚未得到探索。本研究对 54 名健康对照、42 名溃疡性结肠炎 (UC) 和 43 名通过病理检查确诊的克罗恩病 (CD) 患者进行。在所有参与者中，使用 ELISA 试剂盒测量脂联素、Metrnl、白细胞介素 (IL)-6 和肿瘤坏死因子 (TNF-α) 的血清水平。与对照 (107.52 ± 35.33 pg/mL) 相比，UC (85.25 ± 36.55 pg/mL) 和 CD (76.93 ± 27.92 pg/mL) 患者的 Metrnl 浓度显着降低。此外，可以看出，与对照组相比，两个患者组的脂联素水平均降低。除此之外，IL-6 和 TNF-α 水平在患者组中显着升高。此外，结果表明，在对照组和患者中，Metrnl 的水平与体重指数 (BMI) 呈负相关。在两个患者组中，Metrnl 水平也与 IL-6 和 TNF-α 呈负相关。目前的研究是第一个报告 IBD 患者血清中 Metrnl 水平降低的研究，这与 BMI、TNF-α 和 IL-6 呈负相关。这些结果表明 Metrnl 与 IBD 的发病机制可能存在关系，特别是通过炎症过程，尽管有必要进一步研究以剖析可能的机制。结果表明，Metrnl 水平与对照组和患者的体重指数 (BMI) 呈负相关。在两个患者组中，Metrnl 水平也与 IL-6 和 TNF-α 呈负相关。目前的研究是第一个报告 IBD 患者血清中 Metrnl 水平降低的研究，这与 BMI、TNF-α 和 IL-6 呈负相关。这些结果表明 Metrnl 与 IBD 的发病机制可能存在关系，特别是通过炎症过程，尽管有必要进一步研究以剖析可能的机制。结果表明，Metrnl 水平与对照组和患者的体重指数 (BMI) 呈负相关。在两个患者组中，Metrnl 水平也与 IL-6 和 TNF-α 呈负相关。目前的研究是第一个报告 IBD 患者血清中 Metrnl 水平降低的研究，这与 BMI、TNF-α 和 IL-6 呈负相关。这些结果表明 Metrnl 与 IBD 的发病机制可能存在关系，特别是通过炎症过程，尽管有必要进一步研究以剖析可能的机制。