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Adaptive, diverse and de-centralized diagnostics are key to the future of outbreak response
BMC Biology ( IF 4.4 ) Pub Date : 2020-10-28 , DOI: 10.1186/s12915-020-00891-4
Quinn Matthews , Severino Jefferson Ribeiro da Silva , Masoud Norouzi , Lindomar José Pena , Keith Pardee

The global spread of SARS-CoV-2 has shaken our health care and economic systems, prompting re-evaluation of long-held views on how best to deliver care. This is especially the case for our global diagnostic strategy. While current laboratory-based centralized RT-qPCR will continue to serve as a gold standard diagnostic into the foreseeable future, the shortcomings of our dependence on this method have been laid bare. It is now clear that a robust diagnostics pandemic response strategy, like any disaster planning, must include adaptive, diverse and de-centralized solutions. Here we look at how the COVID-19 pandemic, and previous outbreaks, have set the stage for a new innovative phase in diagnostics and a re-thinking of pandemic preparedness.

中文翻译:

自适应,多样化和分散式诊断是暴发应对未来的关键

SARS-CoV-2的全球传播动摇了我们的医疗保健和经济体系,促使人们重新评估长期以来对如何最好地提供医疗服务的观点。对于我们的全球诊断策略而言尤其如此。尽管当前基于实验室的集中式RT-qPCR将在可预见的将来继续作为金标准诊断方法,但我们依赖这种方法的缺点已经暴露出来。现在很清楚,与任何灾难计划一样,强大的诊断大流行应对策略必须包括自适应,多样化和分散式解决方案。在这里,我们了解了COVID-19大流行以及以前的暴发如何为诊断学的新创新阶段和对大流行防范的重新思考奠定了基础。
更新日期:2020-10-30
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