Abstract: Coronavirus disease 2019 (COVID-19) has spread rapidly throughout the world. The range of the disease is broad but among hospitalized patients with COVID-19 are coagulation disorders, pneumonia, respiratory failure, and acute respiratory distress syndrome (ARDS). The excess production of early response proinflammatory cytokines results in what has been described as a cytokine storm, leading to an increased risk of thrombosis, inflammations, vascular hyperpermeability, multi-organ failure, and eventually death over time. As the pandemic is spreading and the whole picture is not yet clear, we highlight the importance of coagulation disorders in COVID-19 infected subjects and summarize it. COVID-19 infection could induce coagulation disorders leading to clot formation as well as pulmonary embolism with detrimental effects in patient recovery and survival. Coagulation and inflammation are closely related. In this review, we try to establish an association between virus infections associated with innate immune activation, inflammation and coagulation activation.

Keywords: COVID-19, coagulation disorders, TLR3, tissue factor


中文翻译：

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COVID-19 中的凝血障碍：Toll 样受体的作用


摘要： 2019 年冠状病毒病（COVID-19）已在世界范围内迅速传播。该疾病的范围很广，但住院的 COVID-19 患者中存在凝血障碍、肺炎、呼吸衰竭和急性呼吸窘迫综合征 (ARDS)。早期反应促炎细胞因子的过量产生会导致所谓的细胞因子风暴，随着时间的推移，导致血栓形成、炎症、血管通透性过高、多器官衰竭以及最终死亡的风险增加。由于大流行正在蔓延，整体情况尚不清楚，我们强调了 COVID-19 感染者凝血障碍的重要性并进行了总结。 COVID-19 感染可能诱发凝血障碍，导致血栓形成以及肺栓塞，对患者的康复和生存产生不利影响。凝血与炎症密切相关。在这篇综述中，我们试图建立与先天免疫激活、炎症和凝血激活相关的病毒感染之间的关联。


关键词： COVID-19、凝血障碍、TLR3、组织因子