Background: Literature survey has pointed out that Benzimidazoles represent an interesting class of anthelmintics, of which several potent members were developed.

Objective: Benzimidazoles hybridized with pharmacophoric moieties possessing anthelmintic activity were designed, synthesized to be evaluated against cercaria.

Methods: Structural modification was achieved through 2- and 5-positions. Moreover, an in vitro cercarial assay was adopted to evaluate target compounds.

Results and Discussions: Biological screening revealed that compound 3h showed significant activity with a survival index of 35% at a 100 μg/mL concentration. Whereas, compounds 3a and 3c showed moderate activity, the rest of the tested compounds exhibited low activity.

Conclusion: The current study evidenced that the new hybrids "benzimidazole-thiophen-aryl" are successful as cercacidal agents. Further studies of this novel tri-ring system are suggested on adult worms of S. mansoni.

背景：文献调查指出，苯并咪唑代表了一种令人关注的驱虫药，其中已开发出多种强效驱虫药。

目的：设计与具有驱虫活性的药效基团部分杂交的苯并咪唑类化合物，合成其对尾c的评价。

方法：通过2位和5位进行结构修饰。此外，采用体外尾car测定法评估目标化合物。

结果与讨论：生物筛选显示，化合物3h在100μg/ mL浓度下显示出显着的活性，存活指数为35％。而化合物3a和3c表现出中等活性，其余受试化合物则表现出低活性。

结论：目前的研究证明，新的杂种“苯并咪唑-噻吩-芳基”可以成功地用作脑酸剂。建议在曼氏沙门氏菌的成虫上对该新颖的三环系统进行进一步研究。