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Hypothetical Proteins as Predecessors of Long Non-coding RNAs
Current Genomics ( IF 1.8 ) Pub Date : 2020-10-22 , DOI: 10.2174/1389202921999200611155418
Girik Malik 1 , Tanu Agarwal 2 , Utkarsh Raj 2 , Vijayaraghava Seshadri Sundararajan 3 , Obul Reddy Bandapalli 4 , Prashanth Suravajhala 5
Affiliation  

Hypothetical Proteins [HP] are the transcripts predicted to be expressed in an organism, but no evidence of it exists in gene banks. On the other hand, long non-coding RNAs [lncRNAs] are the transcripts that might be present in the 5' UTR or intergenic regions of the genes whose lengths are above 200 bases. With the known unknown [KU] regions in the genomes rapidly existing in gene banks, there is a need to understand the role of open reading frames in the context of annotation. In this commentary, we emphasize that HPs could indeed be the predecessors of lncRNAs.

中文翻译:

假设蛋白质是长链非编码 RNA 的前身

假设蛋白 [HP] 是预测在生物体中表达的转录物,但没有证据表明它存在于基因库中。另一方面,长非编码 RNA [lncRNA] 是可能存在于 5' UTR 或基因间区域的转录本,其长度超过 200 个碱基。由于基因组中已知的未知 [KU] 区域迅速存在于基因库中,因此需要了解开放阅读框在注释上下文中的作用。在这篇评论中,我们强调 HPs 确实可能是 lncRNAs 的前身。
更新日期:2020-10-22
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