Serotonin (5-HT) and inflammation are 2 major hypotheses in schizophrenia (SZ) pathogenesis, both of which involve platelets. However, the association between platelet and SZ has not been well studied. The aim of this study was to evaluate changes of platelet count (PLT), mean platelet volume (MPV), platelet-large cell ratio (P-LCR), platelet distribution width (PDW), and plateletcrit (PCT) in patients with first-episode schizophrenia (FES). Meanwhile, 3 inflammation markers, including neutrophil–lymphocyte ratio (NLR), platelet–lymphocyte ratio (PLR), and monocyte–lymphocyte ratio (MLR), were evaluated. Complete blood count of 106 FES patients, 82 first-episode depression (FED) patients, and 120 healthy controls (HCs) were compared. In addition, PLR, NLR, and MLR were calculated and compared among 3 groups. Our data suggested that PLT, MPV, P-LCR, PDW, PCT, NLR, PLR, and MLR in FES patients were significantly increased than those in the HCs (P < 0.01 or P < 0.05, respectively). PLT, PCT, PLR, and MLR in FED patients were significantly higher than those in the HCs (P < 0.01). However, no significant difference in MPV, P-LCR, and NLR was identified between FED patients and HCs (P > 0.05). Moreover, MPV, P-LCR, PDW, NLR, and MLR in FES patients were significantly higher than those in FED patients (P < 0.01 or P < 0.05, respectively). The elevation of PLT, MPV, P-LCR, PDW, PCT, NLR, PLR, and MLR in FES patients supported 5-HT and inflammation hypotheses in SZ pathogenesis. Further, our data suggested that increasing levels of MPV, P-LCR, PDW, NLR, and MLR might help to distinguish FES from FED. Clinical Trials.gov ID: 2018JJ2580

中文翻译：

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首发精神分裂症患者血小板参数升高：一项横断面研究

血清素 (5-HT) 和炎症是精神分裂症 (SZ) 发病机制中的 2 个主要假设，两者都涉及血小板。然而，血小板和 SZ 之间的关联尚未得到很好的研究。本研究的目的是评估血小板计数（PLT）、平均血小板体积（MPV）、血小板-大细胞比（P-LCR）、血小板分布宽度（PDW）和血小板比容（PCT）的变化。 - 发作性精神分裂症 (FES)。同时，评估了 3 个炎症标志物，包括中性粒细胞 - 淋巴细胞比率（NLR）、血小板 - 淋巴细胞比率（PLR）和单核细胞 - 淋巴细胞比率（MLR）。比较了 106 名 FES 患者、82 名首发抑郁症 (FED) 患者和 120 名健康对照 (HC) 的全血细胞计数。此外，计算并比较3组的PLR、NLR和MLR。我们的数据表明 PLT、MPV、P-LCR、P  < 0.01 或P  < 0.05，分别）。FED患者的PLT、PCT、PLR和MLR显着高于HCs（P  < 0.01）。然而，FED 患者和 HC 之间的 MPV、P-LCR 和 NLR 没有显着差异（P  > 0.05）。此外，FES 患者的 MPV、P-LCR、PDW、NLR 和 MLR 显着高于 FED 患者（分别为P  < 0.01 或P  < 0.05）。FES 患者 PLT、MPV、P-LCR、PDW、PCT、NLR、PLR 和 MLR 的升高支持 SZ 发病机制中的 5-HT 和炎症假说。此外，我们的数据表明 MPV、P-LCR、PDW、NLR 和 MLR 水平的增加可能有助于区分 FES 和 FED。临床试验.gov ID：2018JJ2580