Variants c.677 C>T, c.1298 A>C in MTHFR, and c.66 A>G in MTRR Affect the Occurrence of Recurrent Pregnancy Loss in Chinese Women,Genetic Testing and Molecular Biomarkers

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Variants c.677 C>T, c.1298 A>C in MTHFR, and c.66 A>G in MTRR Affect the Occurrence of Recurrent Pregnancy Loss in Chinese Women
Genetic Testing and Molecular Biomarkers ( IF 1.1 ) Pub Date : 2020-11-10 , DOI: 10.1089/gtmb.2020.0106
Yan Zhang _{1,

2} , Wenli Zhan ₁ , Qianyi Du ₁ , Li Wu ₃ , Hongke Ding _{1,

2} , Fenghua Liu ₄ , Aihua Yin _{1,

2}

Affiliation

Objective: Although genetic variants of key enzymes in the folic acid-methionine metabolic circulation, including methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) were thought to be related to the risk of recurrent pregnancy loss (RPL), the results of recent studies have been inconsistent. Therefore, the present retrospective case–control study was designed to explore whether the variants c.66A>G in MTRR and c.677C>T and c.1298A>C in MTHFR are associated with the susceptibility of RPL in Southeast Chinese women.

更新日期：2020-11-15

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