Chemokine-like factor (CKLF)-like MARVEL transmembrane domain containing protein 6 (CMTM6) is a ubiquitously expressed protein, which plays a critical role in the stability of programmed death-ligand 1. However, the expression of CMTM6 in a variety of cancer pathological tissues is not clear. Therefore, 109 patients who were diagnosed with nonsmall cell lung cancer (NSCLC) and underwent surgical resection were included in this retrospective study. The expression of CMTM6 in NSCLC patients' tissue samples were measured by immunohistochemistry and the results showed that 60 cases (55.05%) had high CMTM6 expression. The chi-square test showed that the expression of CMTM6 in NSCLC was significantly related to smoking (p = 0.017) and differentiation (p = 0.029). The Kaplan–Meier survival analysis suggested that the high expression of CMTM6 was associated with better prognosis of NSCLC patients. The univariate analysis revealed that the prognosis of NSCLC patients was correlated with T stage (p = 0.042), lymph node metastasis (p = 0.007), metastasis (p = 0.009), pathological differentiation (p = 0.001), and CMTM6 expression level (p < 0.001). In addition, multivariate analysis indicated that CMTM6 was an independent prognostic factor for NSCLC patients (p = 0.002). CMTM6 expression may have the potential to be a biomarker assisting in disease monitoring and prognosis in NSCLC.

中文翻译：

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CMTM6在非小细胞肺癌中的表达及其临床意义

含趋化因子样因子（CKLF）样的MARVEL跨膜结构域蛋白6（CMTM6）是一种普遍表达的蛋白，在程序性死亡配体1的稳定性中起着关键作用。但是，CMTM6在多种癌症中的表达病理组织尚不清楚。因此，本回顾性研究纳入了109例被诊断为非小细胞肺癌（NSCLC）并接受了手术切除的患者。免疫组织化学法检测NSCLC患者组织中CMTM6的表达，结果显示60例（55.05％）的CMTM6高表达。卡方检验显示CMTM6在NSCLC中的表达与吸烟（p  = 0.017）和分化（p = 0.029）。Kaplan–Meier生存分析表明，CMTM6的高表达与NSCLC患者的预后更好相关。单因素分析显示NSCLC患者的预后与T分期（p  = 0.042），淋巴结转移（p  = 0.007），转移（p  = 0.009），病理分化（p  = 0.001）和CMTM6表达水平相关（p  <0.001）。此外，多因素分析表明，CMTM6是NSCLC患者的独立预后因素（p  = 0.002）。CMTM6的表达可能有可能成为协助NSCLC疾病监测和预后的生物标志物。