Plants of the Euphorbia genus present a wide range of therapeutic applications. This study is aimed at investigating new antidigestive enzyme agents from Euphorbia cyparissias through inhibition of lipid and carbohydrate absorption, to evaluate their potential applications for the treatment of metabolic syndrome. Lipase, phospholipase, protease, α-amylase, β-glucosidase, and xanthine oxidase activities under treatment with aqueous and ethanolic extracts of Euphorbia cyparissias were observed to evaluate the inhibitory effect of these extracts, as well as their antioxidant and cytotoxic effects. Results showed that ethanolic and aqueous extracts exhibited important inhibitory activity in a concentration-related manner on digestive enzymes, which is more effective than the commercial drugs used as controls. Results also showed that, out of the two extracts tested, the ethanolic extract presented the most promising results in inhibiting the activities of all digestive enzymes used. Moreover, the two extracts displayed a higher reducing power than that of the positive control used. The obtained results, together with previous reports in the literature, strongly suggest that Euphorbia cyparissias extracts may be natural inhibitors of the digestive enzymes and thus a potential new drug for metabolic syndrome treatment.

中文翻译：

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一品红提取物的细胞毒性，抗氧化和代谢酶抑制活性。

大戟属植物具有广泛的治疗应用。这项研究的目的是通过抑制脂质和碳水化合物的吸收来研究来自大戟的新的抗消化酶制剂，以评估其在代谢综合征治疗中的潜在应用。大戟半胱氨酸水提取物和乙醇提取物处理后的脂肪酶，磷脂酶，蛋白酶，α-淀粉酶，β-葡萄糖苷酶和黄嘌呤氧化酶活性观察到评价这些提取物的抑制作用以及它们的抗氧化剂和细胞毒性作用。结果表明，乙醇提取物和水提取物以浓度相关的方式对消化酶表现出重要的抑制活性，比用作对照的商业药物更有效。结果还表明，在测试的两种提取物中，乙醇提取物在抑制所用所有消化酶的活性方面表现出最有希望的结果。而且，这两种提取物显示出比所用阳性对照更高的还原力。所获得的结果以及文献中的先前报道有力地表明，大戟大戟 提取物可能是消化酶的天然抑制剂，因此是代谢综合征治疗的潜在新药。