The lower urinary tract symptoms (LUTSs) and acute urinary retention (AUR) caused by benign prostatic hyperplasia (BPH) can seriously affect the quality of life of elderly men. Studies suggest that both androgens and inflammation greatly influence the occurrence and development of BPH in most patients. These two factors combined can also affect each other, leading to pathological changes in the stromal and epithelial tissue of the prostate transition zone in BPH patients. DHT in the prostate tissue of BPH patients may activate a chronic inflammatory response in the prostate, amplifying the expression of inflammatory factors and upregulating the proliferation ability of prostate tissue.

中文翻译：

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雄激素和炎症在良性前列腺增生中的作用和相互作用的综述

良性前列腺增生（BPH）引起的下尿路症状（LUTS）和急性尿潴留（AUR）会严重影响老年男性的生活质量。研究表明，雄激素和炎症都极大地影响了大多数患者 BPH 的发生和发展。这两个因素结合起来也会相互影响，导致 BPH 患者前列腺过渡区的间质和上皮组织发生病理变化。BPH患者前列腺组织中的DHT可能激活前列腺的慢性炎症反应，放大炎症因子的表达，上调前列腺组织的增殖能力。