Electrospun polymer/metal composite nanofibers have received much attention in the field of bone tissue engineering and regenerative medicine (BTERM) owing to their extracellular matrix- (ECM-) like structure, sufficient mechanical strength, favorable biological properties, and bone induction. In particular, electrospun nanofibers containing strontium (Sr) can significantly promote bone repair and regeneration by mediating osteolysis and osteogenesis, which offers a promising bioactive material for BTERM. In this review, we summarized the effects of electrospun nanofibers containing Sr on stem cells, osteoblasts, and osteoclasts in BTERM. Also, current challenges and future perspectives for electrospun nanofibers containing Sr in BTERM are briefly outlined. It is hoped that the systematic overview will inspire the readers to further study Sr-containing nanofibers for BTERM and accelerate their translation from the bench to the clinic.

中文翻译：

---

含锶的电纺纳米纤维，用于骨组织工程

电纺聚合物/金属复合纳米纤维由于其细胞外基质（ECM-）的结构，足够的机械强度，良好的生物学特性以及对骨的诱导作用，因此在骨组织工程和再生医学（BTERM）领域引起了广泛关注。特别是，含有锶（Sr）的电纺纳米纤维可通过介导溶骨作用和成骨作用显着促进骨骼修复和再生，这为BTERM提供了有希望的生物活性材料。在这篇综述中，我们总结了含Sr的电纺纳米纤维对BTERM中干细胞，成骨细胞和破骨细胞的影响。此外，简要概述了BTERM中包含Sr的电纺纳米纤维的当前挑战和未来前景。