Cutaneous melanoma is a significant immunogenic tumoral model, the most frequently described immune phenomenon being tumor regression, as a result of the interaction of tumoral antigens and stromal microenvironment. We present a retrospective cohort study including 52 cases of melanoma with regression. There were evaluated correlations of the most important prognostic factors (Breslow depth and mitotic index) with FOXP3 expression in tumor cells and with the presence of regulatory T cells and dendritic cells in the tumoral stroma. FOXP3 expression in tumor cells seems an independent factor of poor prognosis in melanoma, while regression areas are characterized by a high number of dendritic cells and a low number of regulatory T cells. FOXP3 is probably a useful therapeutical target in melanoma, since inhibition of FOXP3-positive tumor clones and of regulatory T cells could eliminate the ability of tumor cells to escape the immune defense of the host.

中文翻译：

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黑色素瘤中 FOXP3 的回归：肿瘤表达与调节性 T 细胞上调之间


皮肤黑色素瘤是一种重要的免疫原性肿瘤模型，最常描述的免疫现象是肿瘤消退，这是肿瘤抗原和基质微环境相互作用的结果。我们提出了一项回顾性队列研究，包括 52 例黑色素瘤消退病例。评估了最重要的预后因素（Breslow 深度和有丝分裂指数）与肿瘤细胞中 FOXP3 表达以及肿瘤基质中调节性 T 细胞和树突状细胞的存在的相关性。肿瘤细胞中的 FOXP3 表达似乎是黑色素瘤预后不良的独立因素，而消退区的特征是大量树突状细胞和少量调节性 T 细胞。 FOXP3 可能是黑色素瘤的一个有用的治疗靶点，因为抑制 FOXP3 阳性肿瘤克隆和调节性 T 细胞可以消除肿瘤细胞逃避宿主免疫防御的能力。