当前位置: X-MOL 学术J. Chem. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Application of Nanosystems Synergized by Optics and Chemotherapy in the Treatment of Sports Rehabilitation Diseases
Journal of Chemistry ( IF 2.8 ) Pub Date : 2020-10-30 , DOI: 10.1155/2020/7124512
Zhiwei Peng 1, 2 , Xianxiong Li 1 , Yu Zhang 1
Affiliation  

With the rapid development of sports in my country, many athletes will have mild or severe diseases. Physical rehabilitation can improve their physical pain, and some more serious diseases require optical and chemotherapy treatments. This article mainly studies the application of nanosystems that cooperate with optical and chemotherapy in the treatment of sports rehabilitation diseases. In the experiment, the bacteria-infected mice in the wound were divided into 5 groups (n = 4), and the mouse wound model was made. After that, the number of bacteria remaining in the wound was determined by the plate count method. At the same time, a cytotoxicity test was performed, and a control experiment was performed on the cell culture of the polymer at a concentration below the VCR and CMC values. The final sections were used for tissue analysis of serine and epoxy staining. It was found from the experimental data that the cumulative release of free CLB molecules within 3 hours almost reached 100%, and its rapid release was attributed to its small molecular size. In contrast, the release of CLB-HDH micelles in 3 h is 62%, which has a certain relaxation effect. The results showed that CLB-HDH micelles significantly inhibited tumor growth, had good safety in vivo, and had low systemic toxicity. CLB-HDH micelles provide new ideas for efficient CLB tumor treatment.

中文翻译:

光化学协同纳米系统在运动康复疾病治疗中的应用

随着我国体育事业的飞速发展,很多运动员都会出现轻度或重度疾病。身体康复可以改善他们的身体疼痛,一些更严重的疾病需要光学和化学疗法。本文主要研究纳米系统配合光学和化学疗法在运动康复疾病治疗中的应用。实验中将创面感染细菌的小鼠分为5组(n=4),制作小鼠创面模型。之后,通过平板计数法测定伤口中残留的细菌数量。同时进行了细胞毒性试验,对低于VCR和CMC值的聚合物的细胞培养进行了对照实验。最后的切片用于丝氨酸和环氧树脂染色的组织分析。从实验数据中发现,游离CLB分子在3小时内的累积释放几乎达到100%,其快速释放归功于其小分子尺寸。相比之下,CLB-HDH胶束在3h内的释放率为62%,具有一定的松弛作用。结果表明,CLB-HDH胶束显着抑制肿瘤生长,体内安全性好,全身毒性低。CLB-HDH胶束为高效CLB肿瘤治疗提供了新思路。具有一定的放松作用。结果表明,CLB-HDH胶束显着抑制肿瘤生长,体内安全性好,全身毒性低。CLB-HDH胶束为高效CLB肿瘤治疗提供了新思路。具有一定的放松作用。结果表明,CLB-HDH胶束显着抑制肿瘤生长,体内安全性好,全身毒性低。CLB-HDH胶束为高效CLB肿瘤治疗提供了新思路。
更新日期:2020-10-30
down
wechat
bug