Objective. To systematically explore genetic polymorphisms associated with the clinical outcomes in SARS-CoV infection in humans. Methods. This comprehensive literature search comprised available English papers published in PubMed/Medline and SCOPUS databases following the PRISMA-P guidelines and PICO/AXIS criteria. Results. Twenty-nine polymorphisms located in 21 genes were identified as associated with SARS-CoV susceptibility/resistance, disease severity, and clinical outcomes predominantly in Asian populations. Thus, genes implicated in key pathophysiological processes such as the mechanisms related to the entry of the virus into the cell and the antiviral immune/inflammatory responses were identified. Conclusions. Although caution must be taken, the results of this systematic review suggest that multiple genetic polymorphisms are associated with SARS-CoV infection features by affecting virus pathogenesis and host immune response, which could have important applications for the study and understanding of genetics in SARS-CoV-2/COVID-19 and for personalized translational clinical practice depending on the population studied and associated environments.

中文翻译：

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探索与 SARS-CoV 感染结果有关的宿主基因多态性：对 COVID-19 中个性化医疗的影响

客观。系统探索与人类 SARS-CoV 感染临床结果相关的基因多态性。方法。这种全面的文献检索包括根据 PRISMA-P 指南和 PICO/AXIS 标准发表在 PubMed/Medline 和 SCOPUS 数据库中的可用英文论文。结果。位于 21 个基因中的 29 个多态性被确定与主要在亚洲人群中的 SARS-CoV 易感性/抗性、疾病严重程度和临床结果相关。因此，鉴定了涉及关键病理生理过程的基因，例如与病毒进入细胞和抗病毒免疫/炎症反应相关的机制。结论. 尽管必须谨慎，但该系统评价的结果表明，多种基因多态性通过影响病毒发病机制和宿主免疫反应与 SARS-CoV 感染特征相关，这可能对研究和理解 SARS-CoV 的遗传学具有重要应用-2/COVID-19 并根据所研究的人群和相关环境进行个性化的转化临床实践。