CYP24A1 rs1570669 Variant Has a Protective Effect against Tumors of the Urinary System,Public Health Genomics

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CYP24A1 rs1570669 Variant Has a Protective Effect against Tumors of the Urinary System
Public Health Genomics ( IF 1.3 ) Pub Date : 2020-01-01 , DOI: 10.1159/000509190
Yao Sun , Xiang Wang , Jiamin Wu , Zichao Xiong , Haiyue Li , Yuanwei Liu , Jianfeng Liu , Yipeng Ding , Tianbo Jin

Background: Common malignant tumors of the urinary system include renal cell carcinoma, bladder carcinoma, and prostate cancer. The research on the CYP24A1 gene for prostate cancer is mainly concentrated in European and American populations, and there are few studies in the Chinese population. Therefore, we selected bladder cancer, prostate cancer, and renal cancer as the research objects to explore the influence of CYP24A1 on the genetic susceptibility of urinary system tumors. Materials and Methods: rs6068816, rs2296241, rs2762934, and rs1570669 in 529 patients and 523 controls were genotyped via the Agena MassARRAY. Logistic regression analysis was used to evaluate the odd ratios (ORs) and 95% confidence intervals (CIs) of two SNPs with susceptibility of urinary system cancer. Database predicts the expression of the CYP24A1 gene in urinary system cancer. Results: Individuals with the AG genotype of CYP24A1 rs1570669 has a 28% lower risk of developing urinary system tumors (OR = 0.72, 95% CI: 0.56–1.13, p = 0.016) and has a 31% lower risk of developing renal cancer (OR = 0.69, 95% CI: 0.51–0.92, p = 0.012). Conclusions: CYP24A1 rs1570669 may play an important role in the susceptibility of tumors of the urinary system and renal cancer.

更新日期：2020-01-01

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