Objective: The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) is a recently published evidence-based categorization system for salivary gland fine-needle aspiration (FNA). We applied MSRSGC to Japanese cases and evaluated its utility. Study Design: A total of 480 FNA cases were reviewed. We recategorized each case into one of the MSRSGC categories. The risk of neoplasm (RON) and the risk of malignancy (ROM) for each diagnostic category in MSRSGC, and the sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) for malignancy and for neoplasms were calculated for cases with histological follow-up. In addition, the overall ROM (O-ROM) was calculated for all FNA cases. Results: RON, ROM, and O-ROM rates were as follows – non-diagnostic: 51.3, 5.1, and 1.0%; non-neoplastic: 0, 0, and 0%; atypia of undetermined significance: 83.9, 12.9, and 7.3%; neoplasm, benign: 100, 0, and 0%; salivary gland neoplasm of uncertain malignant potential: 100, 32.1, and 23.7%; suspicious for malignancy: 100, 85.7, and 60%; and malignant: 100, 100, 81.8%. The sensitivity, specificity, and accuracy with (without) indeterminate cases for malignancy were 65 (100), 99 (99), 92% (99%) and PPV and NPV were 96 and 100%, respectively, and those for neoplasms were 84 (100), 100 (100), 85% (100%), and PPV and NPV were 100 and 100%, respectively. Conclusions: The MSRSGC is useful for stratification of ROM and for promoting the performance of salivary gland FNA. The MSRSGC could be easily introduced in Japan and may improve the Japanese salivary gland FNA status.
Acta Cytologica

中文翻译：

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米兰系统在涎腺细胞病理学报告中的应用：在一家日本机构中拥有10年的经验

目的：米兰唾液腺细胞病理学报告系统（MSRSGC）是最近发布的基于证据的涎腺细针穿刺抽吸分类系统（FNA）。我们将MSRSGC应用于日本案件并评估了其效用。研究设计：共审查了480个FNA病例。我们将每个案例重新分类为MSRSGC类别之一。MSRSGC中每个诊断类别的肿瘤风险（RON）和恶性肿瘤风险（ROM）以及对恶性肿瘤和肿瘤的敏感性，特异性，准确性，阳性预测值（PPV）和阴性预测值（NPV）分别为为组织学随访病例计算。此外，针对所有FNA情况都计算了总ROM（O-ROM）。结果：RON，ROM和O-ROM率如下-非诊断性：51.3％，5.1％和1.0％；非赘生性：0、0和0％；未定意义的非典型性：83.9、12.9和7.3％；良性肿瘤：100％，0％和0％; 唾液腺肿瘤恶性潜能不确定：100％，32.1％和23.7％；可疑恶性：100％，85.7和60％；和恶性：100、100、81.8％。（不确定）恶性肿瘤的敏感性，特异性和准确性分别为65（100），99（99），92％（99％），PPV和NPV分别为96和100％，而对于肿瘤则为84 （100），100（100），85％（100％）和PPV和NPV分别为100和100％。结论：MSRSGC可用于ROM分层和促进唾液腺FNA的性能。MSRSGC可以很容易地在日本引入，并可以改善日本唾液腺FNA的地位。
细胞学学报