Abstract In this work we analyze the impact of left ventricular assist devices on the systemic circulation in subjects with heart failure associated with left ventricular dilated cardiomyopathy. We use an integrated model of the left heart and blood flow in the systemic arteries with a left ventricular assist device. We study the impact of the rotation speed of the pump on haemodynamic characteristics of distal arteries. We identify the rotation speed for simultaneous recovery of the healthy average values in all systemic arteries, the heart and the aorta. Our numerical experiments show that blood distribution over the graph of systemic vessels does not depend on flow regimes in ascending aorta. We also observe that the optimal pump rotation speed changes in the atherosclerotic vascular network and depends on stenoses localization.

中文翻译：

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左心室辅助装置对体循环的影响分析

摘要 在这项工作中，我们分析了左心室辅助装置对左心室扩张型心肌病相关心力衰竭受试者体循环的影响。我们使用带有左心室辅助装置的左心和全身动脉血流的集成模型。我们研究了泵的转速对远端动脉血流动力学特性的影响。我们确定了所有全身动脉、心脏和主动脉中同时恢复健康平均值的旋转速度。我们的数值实验表明，全身血管图上的血液分布不依赖于升主动脉中的流动状态。我们还观察到动脉粥样硬化血管网络中最佳泵转速的变化取决于狭窄的定位。