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Evolutionary dependencies show paths to cancer development
Nature Genetics ( IF 31.7 ) Pub Date : 2020-10-30 , DOI: 10.1038/s41588-020-00728-4
Martin S Taylor 1
Affiliation  

Patterns of co-occurring and mutually exclusive mutations reveal synergistic interactions among cancer driver genes. A new study functionally confirms these interactions and builds the pairwise relationships into networks of pathway disruption that have better predictive power than specific mutations alone.

中文翻译:

进化依赖性揭示了癌症发展的路径

共发生和相互排斥的突变模式揭示了癌症驱动基因之间的协同相互作用。一项新的研究在功能上证实了这些相互作用,并将成对关系构建到路径破坏网络中,该网络比单独的特定突变具有更好的预测能力。
更新日期:2020-10-30
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