Tight regulation of protein levels is so crucial for cellular function that mammalian cells have evolved two parallel degradation systems. This article discusses how these systems can be exploited to selectively target proteins of interest for therapeutic purposes.

中文翻译：

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通过溶酶体降解细胞外蛋白质

蛋白质水平的严格调节对于细胞功能至关重要，以至于哺乳动物细胞已经进化出两个平行的降解系统。本文讨论了如何利用这些系统选择性地靶向感兴趣的蛋白质以达到治疗目的。