Background: 

The spread of severe acute respiratory syndrome coronavirus 2, causative agent of the coronavirus disease 2019 (COVID-19), has necessitated widespread lockdown to mitigate the pandemic. This study examines the influence of resilience on the impact of COVID-related stress and enforced lockdown on mental health, drug use, and treatment adherence among people living with HIV (PLWH) in Argentina.

Setting: 

PLWH residing predominantly in Buenos Aires Metropolitan Area and urban regions of Argentina were identified from a private clinic electronic database.

Methods: 

Participants completed an anonymous online survey to evaluate the impact of COVID-19 on economic disruption, resilience, mental health outcomes (depression, anxiety, stress, and loneliness), adherence to HIV treatment, and substance use. We performed ordinary least squares and logistic regressions to test whether resilient coping buffered the impact of economic disruption on mental health and drug use during quarantine.

Results: 

A total of 1336 PLWH aged 18–82 were enrolled. The impact of economic disruption on mental health ΔF(1,1321) = 8.86, P = 0.003 and loneliness ΔF(1,1326) = 5.77, P = 0.016 was buffered by resilience. A 3-way interaction between resilient buffering, stress, and sex was significant ΔF(1,1325) = 4.76, P = 0.029. Participants reported less than excellent adherence to medication (33%), disruption to mental health services (11%), and disruption to substance abuse treatment (1.3%) during lockdown.

Discussion: 

The impact of COVID-stress and lockdown on emotional distress seemed mitigated by resilience coping strategies, and the buffering impact of resilience on perceived stress was greater among women. Results highlight PLWH's capacity to adhere to treatment in challenging circumstances and the importance of developing resilience skills for better coping with stress and adversity.

中文翻译：

---

与COVID-19相关的压力和锁定对阿根廷艾滋病毒携带者心理健康的影响

背景： 

严重急性呼吸系统综合症冠状病毒2（冠状病毒病2019（COVID-19）的病原体）的传播已导致必须进行广泛的封锁以缓解大流行。这项研究探讨了抵御力对COVID相关压力的影响以及阿根廷艾滋病毒感染者（PLWH）对精神健康，药物使用和治疗依从性的强制封锁的影响。

设置： 

从私人诊所电子数据库中识别出主要居住在布宜诺斯艾利斯大都会地区和阿根廷市区的艾滋病毒/艾滋病感染者。

方法： 

参与者完成了一项匿名的在线调查，以评估COVID-19对经济中断，适应力，心理健康结局（抑郁，焦虑，压力和孤独），对HIV治疗的依从性以及药物滥用的影响。我们进行了普通最小二乘和逻辑回归分析，以检验在应对隔离期间，弹性应对是否能够缓冲经济中断对心理健康和毒品使用的影响。

结果： 

共有1336名18-82岁的PLWH参加。经济中断对心理健康的影响ΔF（1,1321）= 8.86，P = 0.003和孤独感ΔF（1,1326）= 5.77，P = 0.016受抵御力缓冲。弹性缓冲，压力和性别之间的三向相互作用为显着ΔF（1,1325）= 4.76，P = 0.029。参与者报告说，在禁闭期间，对药物的依从性（33％），对精神卫生服务的中断（11％）和对药物滥用治疗的中断（1.3％）都不够出色。

讨论： 

抵御力应对策略似乎减轻了COVID压力和锁定对情绪困扰的影响，女性抵御力对感知压力的缓冲作用更大。结果突出显示了PLWH在具有挑战性的情况下坚持治疗的能力，以及发展适应能力以更好地应对压力和逆境的重要性。