Background: 

We validated the Data collection on Adverse events of anti-HIV Drugs (D:A:D) full-risk and short-risk score models for chronic kidney disease (CKD) in the Asian HIV cohorts.

Settings: 

A validation study among people living with HIV (PLHIV) aged ≥18 years among the cohorts in the Asia-Pacific region.

Methods: 

PLHIV with a baseline estimated glomerular filtration rate > 60 mL/min/1.73 m² were included for validation of the D:A:D CKD full version and short version without cardiovascular risk factors. Those with <3 estimated glomerular filtration rate measurements from baseline or previous exposure to potentially nephrotoxic antiretrovirals were excluded. Kaplan–Meier methods were used to estimate the probability of CKD development. The area under the receiver operating characteristics was also used to validate the risk score.

Results: 

We included 5701 participants in full model {median 8.1 [interquartile range (IQR) 4.8–10.9] years follow-up} and 9791 in short model validation [median 4.9 (IQR 2.5–7.3) years follow-up]. The crude incidence rate of CKD was 8.1 [95% confidence interval (CI): 7.3 to 8.9] per 1000 person-years in the full model cohort and 10.5 (95% CI: 9.6 to 11.4) per 1000 person-years in the short model cohort. The progression rates for CKD at 10 years in the full model cohort were 2.7%, 8.9%, and 26.1% for low-risk, medium-risk, and high-risk groups, and 3.5%, 11.7%, and 32.4% in the short model cohort. The area under the receiver operating characteristics for the full-risk and short-risk score was 0.81 (95% CI: 0.79 to 0.83) and 0.83 (95% CI: 0.81 to 0.85), respectively.

Conclusion: 

The D:A:D CKD full-risk and short-risk score performed well in predicting CKD events among Asian PLHIV. These risk prediction models may be useful to assist clinicians in identifying individuals at high risk of developing CKD.

中文翻译：

---

亚太地区HIV感染者中D：A：D慢性肾脏病风险评分模型的验证

背景： 

我们验证了亚洲艾滋病毒人群中慢性肾脏病（CKD）的抗HIV药物不良事件（D：A：D）全风险和短期风险评分模型的数据收集。

设定： 

在亚太地区人群中对年龄≥18岁的艾滋病毒感染者（PLHIV）进行的验证研究。

方法： 

包括基线估计肾小球滤过率> 60 mL / min / 1.73 m ²的PLHIV用于验证D：A：D CKD完整版和简短版，无心血管危险因素。从基线或先前暴露于潜在肾毒性抗逆转录病毒药物的肾小球滤过率估计值低于3的患者被排除在外。Kaplan–Meier方法用于估计CKD发生的可能性。接收器工作特性下的区域也用于验证风险评分。

结果： 

我们在全模型{中位数8.1 [四分位间距（IQR）4.8–10.9]年的随访时间}和9791短期模型验证[中位数4.9（IQR 2.5–7.3）年的随访时间]中纳入了5701名参与者。在整个模型队列中，CKD的粗发率是每千人年8.1 [95％置信区间（CI）：7.3至8.9]，而在短时间内每千人年10.5（95％CI：9.6至11.4）模型队列。完整模型队列中CKD在10年时的进展率对于低危，中危和高危组分别为2.7％，8.9％和26.1％，而在全组别中，CKD的进展率为3.5％，11.7％和32.4％。简短的模型队列。全风险和短风险得分在接收器操作特性下的面积分别为0.81（95％CI：0.79至0.83）和0.83（95％CI：0.81至0.85）。

结论： 

D：A：D CKD全风险和短期风险评分在预测亚洲PLHIV人群CKD事件中表现良好。这些风险预测模型可能有助于协助临床医生识别罹患CKD的高风险个体。