ABSTRACT Currently, magnetic applications have great potential for development in the field of drug carriers. In this paper, Fe3O4-PVA@SH, an amphiphilic magnetically targeting drug carrier, was prepared by using Fe3O4 and PVA with thiohydrazide-iminopropyltriethoxysilane(TIPTS). The loading capacity of Fe3O4-PVA@SH on Aspirin and the drug release kinetics of loaded drugs were studied. The obtained Fe3O4-PVA@SH exhibits excellent drug release properties in simulating the human body fluid environment (pH 7.2). Since magnetically targeting drug carriers are readily available and have excellent biocompatibility and the characteristics of drug release. This work’s development, preparing amphiphilic magnetically targeting drug carriers in drug delivery and other fields, has great significance.

中文翻译：

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两亲磁性聚乙烯醇靶向药物载体的制备及给药研究

摘要 目前，磁性应用在药物载体领域具有巨大的发展潜力。本文采用Fe3O4和PVA与硫酰肼-亚氨基丙基三乙氧基硅烷(TIPTS)制备了Fe3O4-PVA@SH，一种两亲磁性靶向药物载体。研究了 Fe3O4-PVA@SH 对阿司匹林的负载能力和负载药物的药物释放动力学。获得的 Fe3O4-PVA@SH 在模拟人体体液环境 (pH 7.2) 中表现出优异的药物释放特性。由于磁性靶向药物载体容易获得并且具有优良的生物相容性和药物释放特性。该工作的开展，制备两亲磁性靶向药物载体在药物递送等领域具有重要意义。