Abstract

Background

The appropriate strategies are needed for stimulating the endogenous neurogenesis or introducing extrinsic neural progenitors, which could be harnessed as the regenerative resources for cueing the neurodegenerations. Adult neurogenesis is the endogenous continuing physiology in limited brain regions such as hippocampus, olfactory system, and hypothalamus. Besides adult neurogenesis, induced pluripotent stem cells (iPSCs) induced functional neurons could be another option for regenerative therapies.

Objective

Current studies are trying to improve the adult neurogenesis and enable the iPSCs induced neurons into neural regeneration. Methods: Here in this review, we mainly introduced the recent progress in neural stem cell biology and its application in the treatment of the neurodegenerations. We main separated the strategy in summarizing the mediators and potential targets to promoting endogenous neural regeneration and transplantation of neural progenitors.

Conclusion

By collecting and comparing the advantages disadvantages between above-mentioned two strategies, we will offer the insight on future development of stem cell therapy in treating neurodegenerative patients.

中文翻译：

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干细胞生物学在治疗神经退行性疾病中的应用

摘要

背景

需要适当的策略来刺激内源性神经发生或引入外源性神经祖细胞，这可以用作提示神经变性的再生资源。成人神经发生是有限大脑区域（如海马、嗅觉系统和下丘脑）的内源性持续生理学。除了成人神经发生，诱导多能干细胞 (iPSC) 诱导的功能性神经元可能是再生疗法的另一种选择。

客观的

目前的研究正试图改善成人神经发生并使 iPSCs 诱导的神经元进入神经再生。方法：本文主要介绍神经干细胞生物学的最新进展及其在神经退行性疾病治疗中的应用。我们主要分离了策略，总结了促进内源性神经再生和神经祖细胞移植的介质和潜在靶点。

结论

通过收集和比较上述两种策略之间的优缺点，我们将为干细胞疗法在治疗神经退行性疾病患者中的未来发展提供见解。