The aim of the present study was the investigation of the effects of mobile phones at different daily exposure times on the hippocampal expression of two apoptotic genes. Forty-eight male BALB/c mice were randomly divided into six groups with 8 animals in each group. Four experimental groups were respectively exposed to electromagnetic waves for 0.5, 1, 2 and 4 hours twice a day for 30 consecutive days. One experimental group was radiated for 4 hours once a day, while the control group did not receive any radiation during the experiment. The expression of both Bax and Bcl2 mRNAs was upregulated in the mice exposed for one and two hours. Whilst the highest expressions were observed in the two-hours radiation in the exposed group, the expression of both studied genes was downregulated in animals with longer exposure to radiation in a duration-dependent manner. The highest ratio of Bax/Bcl2 expression was observed in the mice that received radiation for four hours twice a day. These results revealed that mobile phone radiation can cause considerable changes in the balance of Bax/Bcl2 mRNA expression in laboratory mice hippocampus.

中文翻译：

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长期暴露于手机电磁辐射可导致小鼠海马Bax/Bcl2 mRNA表达平衡发生相当大的变化

本研究的目的是调查每天不同时间接触手机对两种凋亡基因海马表达的影响。48只雄性BALB/c小鼠随机分为6组，每组8只。四个实验组分别暴露于电磁波0.5、1、2和4小时，每天两次，连续30天。一个实验组每天接受一次4小时的辐射，而对照组在实验过程中没有接受任何辐射。Bax 和 Bcl2 mRNA 的表达在暴露一小时和两小时的小鼠中上调。虽然在暴露组的两小时辐射中观察到最高的表达，在长期暴露于辐射的动物中，两种研究基因的表达均以持续时间依赖性方式下调。在每天两次接受辐射四小时的小鼠中观察到最高的 Bax/Bcl2 表达比率。这些结果表明，手机辐射可引起实验室小鼠海马Bax/Bcl2 mRNA表达平衡的显着变化。