ABSTRACT

Background

Alterations in resting-state functional connectivity (rsFC) occur in the acute and chronic phases following traumatic brain injury (TBI); however, few studies have assessed long-term (>1 year) changes in rsFC.

Methods

Resting-state functional magnetic resonance imaging (rsfMRI) scans were obtained from the Federal Interagency Traumatic Brain Injury Research Informatics Systems. Patients with primarily mild TBI (n = 39) completed rsfMRI scans at the sub-acute (~10 days) and long-term (~18 months) phases. We examined changes in voxel-based rsFC from anterior medial prefrontal cortex (aMPFC) and posterior cingulate cortex (PCC) seeds in the default mode network (DMN) between both phases. The effect of age at the time of injury on long-term rsFC was also examined.

Results

Increased rsFC from the aMPFC and the PCC to frontal and temporal regions was shown at ~18-months post-injury. Widespread increases in rsFC from the aMPFC and between the PCC and frontal regions were shown for younger patients at time of injury, but limited increases of rsFC were noted at ~18 months in older patients.

Conclusion

Long-term increases in rsFC were found following TBI, but age at the time of injury was associated with distinct rsFC profiles suggesting that younger patients show greater increases in rsFC over time.

中文翻译：

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受伤时年龄对颅脑外伤内在功能连接的长期变化的影响

摘要

背景

创伤性脑损伤（TBI）后的急性和慢性期会发生静止状态功能连接性（rsFC）的改变。但是，很少有研究评估rsFC的长期（> 1年）变化。

方法

静止状态功能磁共振成像（r sfMRI）扫描是从联邦机构间创伤性脑损伤研究信息系统获得的。例主要是轻度TBI（N = 39）完成- [R sfMRI扫描在亚急性（〜10天）和长期（〜18个月）的相。我们检查了两个阶段之间默认模式网络（DMN）中前内侧前额叶皮层（aMPFC）和后扣带回皮层（PCC）种子中基于体素的rsFC的变化。还检查了受伤时年龄对长期rsFC的影响。

结果

在损伤后约18个月，显示从aMPFC和PCC到额叶和颞叶的rsFC增加。在受伤时，年轻患者的aMPFC以及PCC和额叶区域之间的rsFC广泛增加，但老年患者在约18个月时rsFC的增加有限。

结论

TBI后发现rsFC长期增加，但受伤时的年龄与rsFC的特征明显相关，这表明年轻患者随着时间的推移rsFC的增加更大。