Abstract

Lack of standardized therapeutic approaches is arguably the significant contributor to the high burden of mortality observed in the ongoing pandemic of the Coronavirus disease, 2019 (COVID-19). Evidence is accumulating on SARS-CoV-2 specific immune cell dysregulation and consequent tissue injury in COVID-19. Currently, no definite drugs or vaccines are available against the disease; however initial results of the ongoing clinical trials have raised some hope. In this article, taking insights from the emerging empirical evidence about host-virus interactions, we deliberate upon plausible pathogenic mechanisms and suitable therapeutic approaches for COVID-19.

摘要

缺乏标准化的治疗方法可以说是导致2019年冠状病毒疾病大流行中观察到的高死亡率的重要原因（COVID-19）。关于SARS-CoV-2特异性免疫细胞失调以及随之而来的COVID-19中组织损伤的证据正在积累。目前，尚无针对这种疾病的确切药物或疫苗。然而，正在进行的临床试验的初步结果引起了一些希望。在本文中，我们将从对宿主病毒相互作用的新兴经验证据中得出的见解，探讨了可能的COVID-19致病机制和合适的治疗方法。