ABSTRACT

The protein tyrosine phosphatase non-receptor 22 (PTPN22) R620W polymorphism has been related to susceptibility to autoimmune thyroid disease (AITD) with inconsistent results. Therefore, this meta-analysis was designed to assess a more accurate association between the PTPN22 R620W polymorphism and AITD susceptibility. A systematic search of the EMBASE, PubMed, Web of Science, CBM, CNKI, and WanFang databases was performed to determine relevant publications. Statistical analyses of the odds ratios (ORs), 95% confidence intervals (CIs), and p values were performed using STATA software. Our meta-analysis included 18 separate studies comprised of 4,726 cases and 4,220 controls. In the allele and all genetic models, PTPN22 R620W polymorphism and Graves’ disease (GD) (allele model TvsC: OR = 1.573; 95% CI = 1.378–1.795; P < .001) and Hashimoto’s thyroiditis (HT) (allele model TvsC: OR = 1.737; 95% CI = 1.230–2.454; P = .002) susceptibility was positively associated. A racial subgroup analysis showed that the T allele significantly increased AITD susceptibility in all genetic models involving Caucasians, but not in Asians. This meta-analysis showed that the PTPN22 R620W polymorphism is associated with the risk of GD and HT in the overall study population. In addition, the PTPN22 R620W polymorphism is associated with elevated AITD risk in Caucasians, but not in Asians.

摘要

蛋白酪氨酸磷酸酶非受体 22 (PTPN22) R620W 多态性与自身免疫性甲状腺疾病 (AITD) 的易感性有关，但结果不一致。因此，该荟萃分析旨在评估 PTPN22 R620W 多态性与 AITD 易感性之间更准确的关联。系统检索了 EMBASE、PubMed、Web of Science、CBM、CNKI 和万方数据库以确定相关出版物。优势比 (OR)、95% 置信区间 (CI) 和p的统计分析数值使用 STATA 软件进行。我们的荟萃分析包括 18 项独立研究，包括 4,726 例病例和 4,220 例对照。在等位基因和所有遗传模型中，PTPN22 R620W 多态性和格雷夫斯病 (GD)（等位基因模型 TvsC：OR = 1.573；95% CI = 1.378–1.795；P < .001）和桥本甲状腺炎 (HT)（等位基因模型 TvsC ：OR = 1.737；95% CI = 1.230–2.454；P= .002) 易感性呈正相关。种族亚组分析表明，在所有涉及白种人的遗传模型中，T 等位基因显着增加了 AITD 易感性，但在亚洲人中没有。该荟萃分析表明，PTPN22 R620W 多态性与整个研究人群中的 GD 和 HT 风险相关。此外，PTPN22 R620W 多态性与高加索人的 AITD 风险升高有关，但与亚洲人无关。