ABSTRACT

Abnormality of the immune system may play an important role in the pathogenesis of schizophrenia (SCZ). We aim to investigate the relationship between clinical features of SCZ and tumor necrosis factor-alpha (TNF-α) −238 G/A, −308 G/A polymorphisms in SCZ patients by comparing genotype distributions of TNF-α gene polymorphisms between patients and healthy controls. A sample of 113 patients with SCZ and 104 healthy volunteers was included in the study. SCID-I was used to confirming the diagnosis according to DSM-IV-TR criteria. We evaluated the patients with some scales and data forms in terms of clinical features, symptom severity, level of insight, suicidal behavior, and treatment response. PCR-RFLP was used to determine TNF-α gene polymorphisms from DNA material. The distributions of TNF-α − 238 G/A and TNF-α − 308 G/A polymorphisms of the patients diagnosed with SCZ were not significantly different from the control group. There was a significant difference in the TNF-α − 238 G/A genotype distributions between treatment-resistant and treatment-responsive SCZ patients. Again, the distributions of TNF-α − 238 G/A genotype of attempted suicide patients in SCZ were significantly different from the non-attempted suicide of SCZ patients. Whereas TNF-α − 238 G/A and −308 G/A polymorphisms were not associated with SCZ, TNF-α − 238 G/A polymorphism may be related to treatment resistance and attempted suicide in SCZ patients in the Turkish population.

摘要

免疫系统异常可能在精神分裂症（SCZ）的发病机制中起重要作用。我们旨在通过比较患者之间 TNF-α 基因多态性的基因型分布和健康的对照。该研究包括 113 名 SCZ 患者和 104 名健康志愿者的样本。SCID-I用于根据DSM-IV-TR标准确认诊断。我们根据临床特征、症状严重程度、洞察力水平、自杀行为和治疗反应对患者进行了一些量表和数据形式的评估。PCR-RFLP 用于从 DNA 材料中确定 TNF-α 基因多态性。SCZ患者的TNF-α-238 G/A和TNF-α-308 G/A多态性分布与对照组无显着差异。治疗抵抗性和治疗反应性 SCZ 患者的 TNF-α - 238 G/A 基因型分布存在显着差异。同样，SCZ 中自杀未遂患者的 TNF-α - 238 G/A 基因型分布与 SCZ 患者未尝试自杀的分布显着不同。尽管 TNF-α - 238 G/A 和 -308 G/A 多态性与 SCZ 无关，但 TNF-α - 238 G/A 多态性可能与土耳其人群中 SCZ 患者的治疗抵抗和自杀未遂有关。治疗抵抗性和治疗反应性 SCZ 患者的 TNF-α - 238 G/A 基因型分布存在显着差异。同样，SCZ 中自杀未遂患者的 TNF-α - 238 G/A 基因型分布与 SCZ 患者未尝试自杀的分布显着不同。尽管 TNF-α - 238 G/A 和 -308 G/A 多态性与 SCZ 无关，但 TNF-α - 238 G/A 多态性可能与土耳其人群中 SCZ 患者的治疗抵抗和自杀未遂有关。治疗抵抗性和治疗反应性 SCZ 患者的 TNF-α - 238 G/A 基因型分布存在显着差异。同样，SCZ 中自杀未遂患者的 TNF-α - 238 G/A 基因型分布与 SCZ 患者未尝试自杀的分布显着不同。尽管 TNF-α - 238 G/A 和 -308 G/A 多态性与 SCZ 无关，但 TNF-α - 238 G/A 多态性可能与土耳其人群中 SCZ 患者的治疗抵抗和自杀未遂有关。