ABSTRACT

Introduction: The world is now facing the COVID-19 pandemic. Experience with SARS-CoV and MERS-CoV, and early reports about SARS-CoV-2 infection suggest that health-care settings and health-care workers (HCWs) are vulnerable in the context of the emergence of a new coronavirus.

Areas covered: To highlight the need for prophylactic strategies particularly for HCWs, we identified SARS-CoV, MERS-CoV, and SARS-CoV-2 outbreaks in health-care settings and the incidence of infections in HCWs by a search on MEDLINE and MEDxRIV (for SARS-Cov-2). To identify prophylactic strategies against, we conducted a search on MEDLINE and clinicaltrials.gov about studies involving SARS-CoV, MERS-CoV, and SARS-CoV-2.

Expert opinion: HCWs account for a great part of SARS, MERS, and SARS-CoV-2 infections, they may also contribute to the spread of the disease, particularly in health-care settings, and contribute to nosocomial outbreaks. Some preventive strategies were evaluated in previous emerging coronavirus epidemics, particularly in MERS-CoV. For COVID-19 prevention, different chemoprophylaxis with drug repositioning and new agents are under evaluation, and different vaccine candidates entered clinical development, with clinical trials. HCWs are a crucial target population for pre-exposure and post-exposure prophylaxis.

摘要

介绍

世界现在正面临着COVID-19大流行。过去使用SARS-CoV和MERS-CoV的经验以及有关SARS-CoV-2感染的早期报道表明，在新的冠状病毒出现的背景下，医疗机构和医护人员（HCW）容易受到伤害。

覆盖区域

为了强调特别是针对HCW的预防策略的需求，我们通过搜索MEDLINE和MEDxRIV（针对SARS-Cov- 2）。为了确定预防策略，我们在MEDLINE和Clinicaltrials.gov上搜索了有关SARS-CoV，MERS-CoV和SARS-CoV-2的研究。

专家意见

HCW占SARS，MERS和SARS-CoV-2感染的很大一部分，它们也可能导致疾病传播，特别是在医疗机构中，并导致医院爆发。在先前出现的冠状病毒流行病中，特别是在MERS-CoV中，评估了一些预防策略。对于COVID-19预防，正在评估通过药物重新定位和新药进行的不同化学预防，并且有不同的候选疫苗进入了临床试验和临床试验。HCW是暴露前和暴露后预防的关键目标人群。