ABSTRACT

Introduction

The importance of iron is highlighted by the many complex metabolic pathways in which it is involved. A sufficient supply is essential for the effective production of 200 billion erythrocytes daily, a process called erythropoiesis.

Areas covered

During infection, the human body can withhold iron from pathogens, mechanism termed nutritional immunity. The subsequent disturbances in iron homeostasis not only impact on immune function and infection control, but also negatively affect erythropoiesis. The complex interplay between iron, immunity, erythropoiesis and infection control on the molecular and clinical level are highlighted in this review. Diagnostic algorithms for correct interpretation and diagnosis of the iron status in the setting of infection are presented. Therapeutic concepts are discussed regarding effects on anemia correction, but also toward their role on the course of infection.

Expert opinion

In the setting of infection, anemia is often neglected and its impact on the course of diseases is incompletely understood. Clinical expertise can be improved in correct diagnosing of anemia and disturbances of iron homeostasis. Systemic studies are needed to evaluate the impact of specific therapeutic interventions on anemia correction on the course of infection, but also on patients’ cardiovascular performance and quality of life.

中文翻译：

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细菌感染对红细胞生成的影响

摘要

介绍

铁参与的许多复杂代谢途径突显了铁的重要性。充足的供应对于每天有效生产 2000 亿个红细胞至关重要，这一过程称为红细胞生成。

覆盖区域

在感染期间，人体可以抑制病原体中的铁，这种机制称为营养免疫。随后铁稳态的紊乱不仅会影响免疫功能和感染控制，还会对红细胞生成产生负面影响。本综述强调了铁、免疫、红细胞生成和感染控制在分子和临床水平上的复杂相互作用。介绍了正确解释和诊断感染情况下铁状态的诊断算法。讨论了治疗概念对贫血矫正的影响，但也讨论了它们在感染过程中的作用。

专家意见

在感染的情况下，贫血常常被忽视，它对疾病进程的影响也没有完全了解。在正确诊断贫血和铁稳态紊乱方面可以提高临床专业知识。需要系统研究来评估特定治疗干预对贫血纠正对感染过程的影响，以及对患者心血管功能和生活质量的影响。