ABSTRACT

Reticulophagy, a type of selective autophagy that specifically targets and degrades parts of the endoplasmic reticulum (ER) network (sheets or tubules), plays a crucial role in the responses to ER stress. The selectivity of the ER cargo recognition relies on the unique reticulophagy receptors, which tether and deliver cargos to phagophores, the precursors to autophagosomes. Various integral membrane proteins have been well characterized as reticulophagy receptors, including Atg39, Atg40, RETREG1/FAM134B, SEC62, RTN3L, CCPG1, TEX264, and ATL3, in both yeast and mammals in the past five years. In a recent paper, Zhao et al. discovered in fission yeast a novel reticulophagy receptor, Epr1, which bridges the ER and phagophore by binding to Atg8 and VAPs, a mechanism different from the aforementioned reticulophagy receptors.

摘要

网状自噬是一种选择性自噬，专门针对和降解内质网 (ER) 网络（片或小管）的一部分，在对 ER 应激的反应中起着至关重要的作用。ER 货物识别的选择性依赖于独特的网状吞噬受体，这些受体将货物连接并运送到自噬体的前体吞噬细胞。在过去的五年中，各种整合膜蛋白已被很好地表征为网状吞噬受体，包括 Atg39、Atg40、RETREG1/FAM134B、SEC62、RTN3L、CCPG1、TEX264 和 ATL3，在酵母和哺乳动物中。在最近的一篇论文中，赵等人。在裂殖酵母中发现了一种新的网状吞噬受体 Epr1，它通过与 Atg8 和 VAP 结合来桥接 ER 和吞噬细胞，这是一种不同于上述网状吞噬受体的机制。